ePAC, a novel cancer vaccine utilizing a mammalian-derived virus-like particle to co-deliver neoantigens and CpG-ODN, demonstrates strong antitumor efficacy in mouse models.
The cannabinoids cannabidiol, cannabidivarin, and the newly identified 331-18A demonstrate antitumoral effects in Notch1-mutated leukemia, underscoring the potential and complexity of Cannabis as a novel treatment for cancer.
Inhibiting the RiBi pathway impedes both EMT and MET processes, enhancing chemotherapy efficacy and presenting a novel avenue to tackle advanced breast cancer treatment resistance.
Sila Gerlevik, Nogayhan Seymen ... Mohammad M Karimi
Multi-omics factor analysis reveals transposable element expression as a risk factor and inflammation as a protective factor in myelodysplastic syndromes (MDS).
Phaedra C Ghazi, Kayla T O'Toole ... Martin McMahon
Inhibiting KRASG12C and ULK-mediated autophagy is a novel treatment strategy to control the growth of KRASG12C-driven lung cancer in preclinical models of lung cancer.
Anastasia D Komarova, Snezhana D Sinyushkina ... Marina V Shirmanova
The level of heterogeneity of cellular energy metabolism increases with model complexity and is the highest in patients' tumors, which can be observed and quantified using FLIM of NAD(P)H.
MYCN and TFIIIC exert a censoring function during early transcription, limiting the accumulation of inactive RNAPII at the promoter and facilitating promoter-proximal degradation of nascent RNA.
The immune microenvironment has a pivotal role in hepatocellular carcinoma (HCC) progression and immune therapy resistance, and targeting this complex milieu holds great promise for improving therapeutic outcomes and patient prognoses in HCC management.
