Browse our latest Cancer Biology articles

Modeling glioblastoma using expression of relevant human oncogenes in syngeneic zebrafish offers a powerful platform for current and future biological discovery, diagnostics, and therapeutic testing in an intact tumor microenvironment.

Establishing a zebrafish model of a deadly type of brain tumor highlights the role of the immune system in the early stages of the disease.

P-body is a new downstream effector of YAP/TAZ for tumorigenesis and tumor progression, suggesting disruption of P-bodies as a potential therapeutic strategy for tumors with active YAP.

Extending the period of remission for cancer patients requires new knowledge of dormant, residual disease and Netrin signaling contributes to the survival of dormant cells in ovarian cancer.

Findings identify a new link between oncogenic ß-catenin and exosome biogenesis, which may serve as an important nodal point in the immune escape of hepatocellular carcinoma.

RBM7 functions as a novel regulator of MFGE8 alternative splicing and p65 phosphorylation to counteract the metastatic potential of breast cancer, offering novel mechanistic insights into how abnormal splicing contributes to tumor aggressiveness.

Cancer cell antigen presentation, a requirement for immune-mediated tumor rejection, is induced by dihydroorotate dehydrogenase-inhibitor-mediated cancer cell pyrimidine nucleotide depletion via P-TEFb-dependent transcriptional upregulation of MHC-I and related genes.

Macropinocytosis of the signalling receptor LPAR1, by an actin and CYRI-B-dependent mechanism, impacts on progression and spread of pancreatic cancer in a mouse model.