Browse our latest Cancer Biology articles

Bariatric surgery reversed obesity-exacerbated tumor burden and increased efficacy of anti-PD-L1 immunotherapy.

Inhibition of GOT2 drives growth inhibitory reductive stress that can be rescued by electron acceptors in vitro, whereas GOT2 inhibition in endogenous or transplanted tumor models is tolerated without consequence, highlighting the importance of context when studying tumor metabolism.

In response to proteotoxic stress, squamous cell carcinoma cells hijack the integrated stress response to promote recovery by bolstering protection of microtubule dynamics.

Comprehensive proteomic investigation and functional studies unravel an essential role of differentiated glioma cell-secreted fibromodulin (FMOD) in regulating glioblastoma tumor growth by inducing angiogenesis by activating integrin-dependent Notch signaling in endothelial cells, highlighting FMOD as a potential therapeutic target.

Cystathionine-β-synthase is a novel metabolic regulator of AKT-induced senescence and a potential tumor suppressor in gastric cancer pathogenesis which can be harnessed to target PI3K/AKT-driven cancers.

Genome-wide CRISPR screens in human cells identifies a role for TRIM37 in growth arrest after chemical inhibition of PLK4.

Effective antiestrogens engage a new structural interaction to improve therapeutic antagonism in hormone-resistant breast cancer cells expressing Y537S estrogen receptor alpha.

Method NEAdriver employs knowledge from global networks to predict novel cancer driver genes in an individualized manner, which is done by accounting for mutations’ co-occurrence in each tumor genome and rigorous statistical evaluation.

Late effects of radiation therapy in mice can be prevented by treatment with either senolytics navitoclax or quercetin plus dasatinib or the senostatic metformin.

A comprehensive molecular interrogation of CREB5 interactions identified changes in protein and chromatin interactions of FOXA1 that promoted therapy resistance in prostate cancer cells.