Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.
Genetic and biochemical studies show that SETD2 is tumor suppressive in a lung cancer mouse model and SETD2 methylation activity in vitro is regulated by histone acetylation.
The hemogenic gastruloid model of embryonic blood development captures multi-wave haematopoiesis and enables interrogation of infant leukaemia cell-of-origin.
A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.
Connor Hill, Alexandra Indeglia ... Alessandro Gardini
Molecular profiling with omics approaches reveals the resemblance between neuroendocrine malignancies and solitary fibrous tumors, rare soft tissue cancers with no effective treatment options.
NOLC1 inhibits p53 nuclear accumulation and transcription, subsequently suppresses cisplatin-induced ferroptosis, and promotes an immunosuppressive microenvironment, eventually suppressing immunochemotherapy in gastric cancer.
