Browse our latest Cancer Biology articles

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    1. Cancer Biology

    STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer

    Stephen D'Amico, Varvara Kirillov ... Nancy C Reich
    Results show that STAT3 and KRAS jointly regulate oncogenic dependency of mutant KRAS cancer cells.
    1. Computational and Systems Biology
    2. Cancer Biology

    Robust estimation of cancer and immune cell-type proportions from bulk tumor ATAC-Seq data

    Aurélie AG Gabriel, Julien Racle ... David Gfeller
    1. Cancer Biology

    FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

    Chenxi Gao, Huaibin Ge ... Jing Hu
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Water-soluble 4-(dimethylaminomethyl)heliomycin exerts greater antitumor effects than parental heliomycin by targeting the tNOX-SIRT1 axis and apoptosis in oral cancer cells

    Atikul Islam, Yu-Chun Chang ... Pin Ju Chueh
    Multifaceted properties of the water-soluble derivative of antibiotic heliomycin enable it to offer greater antitumor value than its parent compound by inhibiting the tNOX-NAD+-SIRT1 axis to induce apoptosis.
    1. Cancer Biology
    2. Computational and Systems Biology

    Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

    Sara Latini, Veronica Venafra ... Francesca Sacco
    Acute myeloid leukemia-specific predictive logic models reveal new therapeutic targets involved in cancer resistance mechanisms paving the way for personalized precision medicine.
    1. Cancer Biology

    Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

    Jing Xie, Yafei Xu ... Qiancheng Song
    Osteocytes, sensing mechanical stimulation generated by exercise, inhibit the proliferation of non-small cell lung cancer cells and sustain their dormancy by releasing small extracellular vesicles containing tumor-suppressive micro-RNAs.
    1. Cancer Biology

    Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

    Wanyoung Lim, Inwoo Hwang ... Sungsu Park
    A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.
    1. Cancer Biology
    2. Computational and Systems Biology

    A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

    Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
    A robust machine learning diagnostic platform utilizing exosome proteins to distinguish various human cancers in diverse biological fluids.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    The DBD-α4 helix of EWS::FLI is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma

    Ariunaa Bayanjargal, Cenny Taslim ... Emily R. Theisen
    1. Cancer Biology

    Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

    Fei Yue, Amy T. Ku ... Yi Li
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