Browse our latest Cancer Biology articles

Pharmacological disruption of TopBP1 condensation impairs ATR signaling, promotes DNA damage and apoptosis, and enhances the efficacy of FOLFIRI chemotherapy in colorectal cancer.

A unique pathogenic mutation on the primary prolyl hydroxylase of the oxygen-sensing pathway compromises the capacity to hydroxylate the hypoxia-inducible factor's N-terminal oxygen-dependent degradation domain proline while retaining activity against the otherwise catalytically predominant C-terminal proline.

BEHAV3D Tumor Profiler enables researchers without computational expertise to uncover heterogeneous cell behaviors and explore their relationships with microenvironmental features in intravital microscopy data.

KDM5 inhibition/disruption selectively induces R-loop-mediated DNA damage and innate immune activation in breast cancer cells, while sparing normal cells, unveiling a tumor-specific therapeutic vulnerability with broad translational potential.

Genetic information in cancer cells reveals the strength of cancer–immune interactions in an individual-based stochastic model, which captures explicit interactions between cancer and effector cells.

Telomere length controls hTERT expression by modulating TRF2 distribution and PRC2-mediated repression, highlighting a self-regulatory mechanism in cancer.

A novel compound that inhibits the BAF chromatin remodeling complex causes regression in an animal model of the incurable cancer uveal melanoma.