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    1. Cancer Biology
    2. Cell Biology

    Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications

    Ida Marie Boisen, Nadia Krarup Knudsen ... Martin Blomberg Jensen
    Testicular microcalcifications arise secondary to local alterations in mineral homeostasis, which in combination with impaired Sertoli cell function and reduced levels of mineralization inhibitors facilitate deposition of hydroxyapatite.
    1. Cancer Biology

    Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

    Patrick B Jonker, Mumina Sadullozoda ... Alexander Muir
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Cell Biology
    2. Cancer Biology

    A single cysteine residue in vimentin regulates long non-coding RNA XIST to suppress epithelial-mesenchymal transition and stemness in breast cancer

    Saima Usman, W Andrew Yeudall ... Ahmad Waseem
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

    Qianqian Ju, Wenjing Sheng ... Cheng Sun
    TAK1 plays a negative role in esophageal squamous cancer cell metastasis, which depends on the TAK1-induced phosphorylation of PLCE1 at S1060 and subsequent inhibition of PIP2 hydrolysis.
    1. Cell Biology
    2. Cancer Biology

    DuoHexaBody-CD37 induces direct cytotoxic signaling in diffuse large B-cell lymphoma

    Simar Pal Singh, Michelle D van den Beukel ... Annemiek B van Spriel
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology
    2. Cell Biology

    Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Cell crowding drives a pro-invasive mechanotransduction pathway in high-grade DCIS, inducing TRPV4 inhibition, calcium and cell volume reduction, and increased invasion, with compensatory plasma-membrane TRPV4 relocation indicating pathway activation.
    1. Cancer Biology
    2. Cell Biology

    Breast Cancer: How cell crowding causes cancer cells to spread

    Rui Hua, Jean X Jiang
    Cell crowding causes high-grade breast cancer cells to become more invasive by activating a molecular switch that causes the cells to shrink and spread.
    Version of Record
    Insight
    1. Cancer Biology

    Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

    Liuqun Zhao, Tanel Punga, Suparna Sanyal
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology
    2. Genetics and Genomics

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy Lu
    Pairwise CRISPR screen identified FYN and KDM4 as key regulator of tyrosine kinase inhibitor resistance in triple negative breast cancer (TNBC).
    1. Cancer Biology
    2. Evolutionary Biology

    Cancer-immune coevolution dictated by antigenic mutation accumulation

    Long Wang, Christo Morison, Weini Huang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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