The local PI(4,5)P2 nanodomain promotes the dimerization and activation of EGFR in the plasma membrane, whereas activated EGFR dissolves the nanodomain structure of PI(4,5)P2 through PLCγ.
A plant autophagy pathway transports chloroplast stroma and envelope components into the vacuole through the division and encapsulation of the site of chloroplasts that is associated with developing autophagosome.
Formation of a giant unilocular vacuole through a macropinocytosis-like process in cells with disrupted actin cytoskeleton promotes resistance to anoikis.
Two alternative models of PKA activation were tested in neurons, and the results support the classical model in which the catalytic subunit dissociated from the regulatory subunit upon activation.
Chromatin immunoprecipitation sequencing and RNA sequencing have elucidated the complex transcript regulation pathways orchestrated by SntB, pivotal for Aspergillus flavus's development, mycotoxin production, and virulence.
SIRT4 regulates cellular communication network factor 2 expression through U2 small nuclear RNA auxiliary factor 2-mediated pre-mRNA splicing, presenting a potential therapeutic target for kidney fibrosis.
