Testosterone promotes the conversion of glucose to fatty acids by increasing the expression of ACLY in seminal vesicle epithelial cells, thereby regulating the seminal plasma components.
Combined with high-throughput yeast genetics, a split green fluorescent protein encoded directly in the mitochondrial DNA helps to identify targeting signals and functions of dually localized proteins.
Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.
Teresa Almeida, Eleanor Hargreaves ... Igor Barsukov
Structural analysis reveals a two-step EB1-SxIP binding mechanism and identifies ligand mutations that greatly enhance affinity, offering potential therapeutic avenues for targeting microtubule plus end interactions.
Quantitative Drosophila pupal wing experiments support planar polarity depending on cell-scale signalling that does not involve depletion of a limited pool of core proteins or polarised transport on microtubules.
