The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.
ACVR2A downregulation disrupts the TCF7/c-JUN pathway, impairing trophoblast invasion and proliferation in pre-eclampsia, revealing a genetic susceptibility-associated mechanism of placental dysfunction.
Elise Miedlar, Grace E Hamilton ... Trisha N Davis
Biochemical reconstitution and laser trapping show that centromeric DNA sequences are important for the transmission of microtubule-based forces to chromosomes.
A single protein can switch cellular behaviors from protrusion to retraction based on its concentration and dynamics, revealing a novel mechanism for controlling antagonistic phenotypes in cell signaling.
