Browse our latest Cell Biology articles

Page 14 of 323
    1. Cell Biology

    Senescence: Returning aging cells to productivity

    Rachana S Vaidya, Simon Y Tang
    Platelet-derived growth factors can restore the proliferative potential of senescent cells taken from the degenerated intervertebral discs of aged humans.
    Version of Record
    Insight
    1. Cell Biology

    Forward genetics in C. elegans reveals genetic adaptations to polyunsaturated fatty acid deficiency

    Delaney Kaper, Uroš Radović ... Marc Pilon
    Polyunsaturated fatty acids are not genetically replaceable in the nematode C. elegans and only mutations that help free ferrous ions can boost the activity of a poorly functioning desaturase enzyme.
    1. Cell Biology
    2. Medicine

    The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

    Fan Zhang, Yuan Wang ... Xianpeng Ge
    CHMP5 is crucial in preventing skeletal progenitor cell senescence and abnormal bone formation, and senolytic drugs represent potential therapeutic medicine for musculoskeletal abnormalities associated with a dysfunctional endolysosomal pathway.
    1. Cell Biology

    The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast

    Jacob H Cecil, Cristina M Padilla ... Andrew P Capaldi
    Dual regulation of TORC1 by Gtr1/2 and Pib2 drives cells into three distinct signaling states, establishing a new paradigm for graded TORC1 signaling.
    1. Cell Biology
    2. Developmental Biology

    Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution

    Julie Uveira, Antoine Donati ... Tsuyoshi Momose
    The jellyfish embryonic body axis is globally coordinated by conserved planar cell polarity (PCP) mechanisms and oriented by localised Wnt3 in two steps, highlighting PCP’s role in animal axis evolution.
    1. Cell Biology

    Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

    Francesco Marocco, Sabrina Garbo ... Marco Tripodi
    PCBP2 promotes miRNA cell retention by counteracting SYNCRIP-dependent miRNAs EV loading.
    1. Cell Biology

    FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall

    Jewel T-Y Li, Mehdi Amiri ... Wayne S Sossin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation

    Abhishek Kumar, Keiichiro Tanaka, Martin A Schwartz
    Focal adhesion derived p130Cas condensates regulate translation in an adhesion strength dependent manner.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway

    Lan Yao, Wanwan Zhang ... Kuntong Jia
    MYL3 is identified as a novel receptor enabling nervous necrosis virus (NNV) entry via macropinocytosis, revealing a therapeutic target for combating NNV outbreaks in aquaculture.
    1. Cell Biology
    2. Neuroscience

    CellSeg3D, Self-supervised 3D cell segmentation for fluorescence microscopy

    Cyril Achard, Timokleia Kousi ... Mackenzie Weygandt Mathis
    Self-supervised deep learning models can accurately perform 3D segmentation of cell nuclei in complex biological tissues, enabling scalable analysis in settings with limited or no ground truth annotations.