Hexokinases regulate the metabolic transcription factor MML-1 via distinct pathways, linking glucose metabolism and organellar signaling to longevity control in Caenorhabditis elegans and mammals.
Alaknanda Emery, Orest W Blaschuk ... Darryl L Russell
A critical role for N-cadherin in ovarian follicular development and ovulation is demonstrated with inhibitors or knockout of N-cadherin shown to inhibit ovulation by blocking mechanotransduction of ovulatory genes.
Uncovering a novel PDE1A/YTHDF2/STAT3 pathway in non-small cell lung cancer (NSCLC) progression also provides therapeutic strategies for treating NSCLC patients with metastasis.