Polysome formation within the nucleoid and repulsion between these major cytoplasmic components provide a self-organizing mechanism for chromosome segregation and modulation of its timing across growth rates in Escherichia coli.
AlphaFold-guided in vitro and in vivo analyses establish the mechanism of ULK complex formation and provide a structural basis for understanding its role in mammalian autophagy initiation.
Subcellular sequestration of caspase near membrane-associated proteins enables its non-lethal activation, which modulates neuronal function and innate olfactory behavior in the adult Drosophila olfactory receptor neurons.
Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.
