The scaffold Bem1 increases the rate of GEF-mediated Cdc42 activation, while also increasing the rate and extent of GEF phosphorylation by PAK, which attenuates further scaffold stimulation.
Wilhelmina E van Riel, Ankit Rai ... Anna Akhmanova
Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.
Christoph A Bücherl, Iris K Jarsch ... Cyril Zipfel
Although genetically and biochemically linked, the plant immune and growth receptors FLS2 and BRI1 form dispersed receptor clusters within the plasma membrane that are spatiotemporally separated.
Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.
Mitsuhiro Endoh, Takaho A Endo ... Haruhiko Koseki
PCGF6 links sequence specific target recognition by the MAX/MGA transcription factor complex to PRC1 (polycomb repressive complex 1) -dependent transcriptional silencing of germ cell-specific genes in mouse pluripotent stem cells.
In contrast to current knowledge that predicts that apicomplexan actin is unconventional, use of Chromobodies demonstrate that Toxoplasma F-actin forms a long, stable, highly dynamic tubular network that is required for material transfer and parasite maturation.
Annette Fischer, Kelly S Harrison ... Thomas Rudel
Obligate intracellular Chlamydia secrete a deubiquitinating enzyme (Cdu1) into the membrane of the Chlamydia-containing vacuole to deubiquitinate selected host proteins and support the survival of the bacteria during genital infection.