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Evolutionarily unrelated microtubule and actin regulatory factors use the same mechanism to accelerate polymerization.

Metabolic dysfunction-associated steatotic liver disease is associated with reduced mitochondrial cardiolipin concentration in mice and humans, and cardiolipin deficiency was sufficient to drive steatosis and fibrosis in the liver.

SETD6-mediated methylation of PPARγ establishes a positive feedback mechanism that enhances transcriptional activation and promotes hepatic lipid accumulation.

The Z-disc of muscle sarcomeres is a solid aggregate stabilized by the intrinsically disordered region of the Alp/Enigma family protein Zasp52.

Restoring endolysosomal membrane fluidity limits tau seed escape, seeded aggregation, and neuronal toxicity in cell and animal models.