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    1. Cell Biology
    2. Genetics and Genomics

    Kinesin-2 autoinhibition requires elbow phosphorylation

    Guanghan Chen, Zhengyang Guo ... Guangshuo Ou
    Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.
    1. Cancer Biology
    2. Cell Biology

    RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

    Junjun Huang, Rong Jia, Jihua Guo
    Upregulated by HOXA10, RUNX2 isoform II transactivates PRDX2 expression and inhibits ferroptosis and apoptosis in oral squamous cell carcinoma.
    1. Cell Biology
    2. Genetics and Genomics

    Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

    San Pin Steve Wu, Elvis Quiroz ... Francesco J DeMayo
    Genome-wide epigenetic profiling reveals chromatin regions in the human myometrium involved in functional regulation and hormonal control during pregnancy.
    1. Cell Biology

    A Commander-independent function of COMMD3 in endosomal trafficking

    Galen T Squiers, Chun Wan ... Jingshi Shen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Cell Biology

    Clearance of protein aggregates during cell division

    Shoukang Du, Yuhan Wang ... Ting Gang Chew
    ER aggregates confined in the nucleus are cleared via ER reorganization when cells progress through mitosis and cytokinesis.
    1. Cell Biology
    2. Cancer Biology

    PRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis

    Hairui Su, Yong Sun ... Xinyang Zhao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

    Yueliang Zhang, Sara B Noya ... Amita Sehgal
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic β cells

    Kai M Bracey, Margret Fye ... Irina Kaverina
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Compelling
    1. Cell Biology
    2. Developmental Biology

    The oocyte zinc transporter Slc39a10/Zip10 is a regulator of zinc sparks during fertilization in mice

    Atsuko Kageyama, Narumi Ogonuki ... Junya Ito
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cell Biology

    HNF4α-TET2-FBP1 axis contributes to gluconeogenesis and type 2 diabetes

    Hongchen Li, Xinchao Zhang ... Yanping Xu
    Functional analyses reveal the HNF4α-TET2-FBP1 axis as a critical regulator of gluconeogenesis, type 2 diabetes (T2D) progression, and metformin’s therapeutic effects, which proposes TET2 as a promising therapeutic target for T2D.
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