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A multi-tissue proteomic atlas uncovers the shared and distinct molecular signatures of metabolic flexibility induced by intermittent fasting.

Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects cargo recognition to motor activation.

Mechanosensitive recruitment of DLC1 to focal adhesions creates a positive feedback loop that locally amplifies Rho activation in response to tension.

A system to enrich yeast in metaphase of mitosis, meiosis I, or meiosis II reveals reduced spindle assembly checkpoint robustness in meiosis I and distinct kinetochore composition and phosphorylation states.

A genetic toolkit establishes Drosophila as a tractable metazoan system for systematic interrogation of conserved biological functions of the ancient polymer polyphosphate.

Dysregulated exocytosis of bis(monoacylglycerol)phosphate (BMP)-enriched extracellular vesicles driven by pathogenic LRRK2 activity supports elevated urinary BMP levels and its use as a biomarker for Parkinson's disease.