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Src-like adaptor protein (SLAP) preserves intestinal epithelial homeostasis by restraining Src-family kinase signaling, revealing a non-genetic mechanism limiting colorectal tumor initiation.

A genome-wide RNA interference screen identified cellular processes that modulate the phase separation of a TDP-43 mutant, providing a framework for dissecting the link between its phase behavior and disease-associated aggregation.

An actin-nucleation-dependent assembly of the axonal membrane skeleton reveals that βII-spectrin gap-and-patch patterns in human motor neurons represent an intermediate stage of cytoskeletal maturation.

Single-cell observations refute the expectation that centrosome positioning is critical for epithelial cell polarization while showing that proper positioning enhances polarization efficiency.

Polo-like kinase phosphorylation of the centrin arm-localized orphan kinesin KIN-G disrupts its microtubule-binding activity and inhibits centrin arm biogenesis in trypanosomes.

Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.

Evolutionarily unrelated microtubule and actin regulatory factors use the same mechanism to accelerate polymerization.

Metabolic dysfunction-associated steatotic liver disease is associated with reduced mitochondrial cardiolipin concentration in mice and humans, and cardiolipin deficiency was sufficient to drive steatosis and fibrosis in the liver.