Single-cell observations refute the expectation that centrosome positioning is critical for epithelial cell polarization while showing that proper positioning enhances polarization efficiency.
Polo-like kinase phosphorylation of the centrin arm-localized orphan kinesin KIN-G disrupts its microtubule-binding activity and inhibits centrin arm biogenesis in trypanosomes.
Jenny A Hurcombe, Lusyan Dayalan ... Richard JM Coward
Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.
Marisa J Brothwell, Guoshen Cao ... Katsuhiko Funai
Metabolic dysfunction-associated steatotic liver disease is associated with reduced mitochondrial cardiolipin concentration in mice and humans, and cardiolipin deficiency was sufficient to drive steatosis and fibrosis in the liver.
