Intracellular zinc dynamically changes during sperm capacitation and regulates Slo3-mediated hyperpolarization, while directly inhibiting Slo3 currents through residues contributing to its slow dissociation.
Daniel Beaudet, Christopher L Berger, Adam G Hendricks
Single-molecule motility assays and live-cell imaging in neurons reveal that tau hyperphosphorylation disrupts the formation of cooperative tau envelopes along microtubules and lysosomal transport.
In vivo live imaging, quantitative analysis, and computational modeling reveal that wound-induced epithelial cell fusion accelerates epithelial repair through several likely mechanisms.
OCRL deficiency is associated with mitochondrial dysfunction, altered ciliary signaling, and disrupted neural cell-state regulation across multiple experimental models of Lowe syndrome.
Daniel Haertter, Lara Hauke ... Christoph F Schmidt
A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.
