Functional analyses reveal the HNF4α-TET2-FBP1 axis as a critical regulator of gluconeogenesis, type 2 diabetes (T2D) progression, and metformin’s therapeutic effects, which proposes TET2 as a promising therapeutic target for T2D.
The development of an automated micronucleus segmentation program enables population-level comparisons between cells with and without micronuclei and defines a highly limited response to micronucleus formation or rupture.