Endosomes operate several exit routes that sort protein cargo and depend on pathway-specific associations of a PROPPIN with the responsible protein coat, such as the here identified CROP2, to support the departure of the cargo carriers.
Fangrui Guo, Roberto Ornelas Guevara ... Guy Tran Van Nhieu
Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca2+ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infection.
Crystal R Noell, Tzu-Chen Ma ... William O Hancock
All three kinesin transport families exhibit unexpectedly slow dissociation under load, explaining robust competition with dynein during bidirectional cargo transport.
The loss of FMRP does not affect how neuronal ribosomes are stalled or where they are stalled, but reduces the number of neuronal RNA granules that contain stalled ribosomes.
Simar Pal Singh, Kumar Mangalam ... Annemiek B van Spriel
DuoHexaBody‑CD37 triggers complement‑independent cytotoxic signaling in diffuse large B-cell lymphoma (DLBCL), revealing therapeutic pathways that can be exploited to enhance tumor cell killing through targeted combination strategies.
