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    1. Cell Biology

    Functional High Throughput Drug Screening Reveals Cyproheptadine as a Novel Treatment for LMNA-related Cardiomyopathy

    Hananeh Fonoudi, Ali Negahi Shirazi ... Paul W Burridge
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells

    Noa Nashnaz, Dana Goldberg ... Dan Levy
    SETD6-mediated methylation of PPARγ establishes a positive feedback mechanism that enhances transcriptional activation and promotes hepatic lipid accumulation.
    1. Cell Biology

    Zasp52’s differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc

    Nikolai Ho, Frieder Schöck
    The Z-disc of muscle sarcomeres is a solid aggregate stabilized by the intrinsically disordered region of the Alp/Enigma family protein Zasp52.
    1. Cell Biology

    Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

    Jessica Tittelmeier, Carl Alexander Sandhof ... Carmen Nussbaum-Krammer
    Restoring endolysosomal membrane fluidity limits tau seed escape, seeded aggregation, and neuronal toxicity in cell and animal models.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A genetic toolkit for stable transgenesis in the anaerobic gut parasite Blastocystis ST7-B

    M Rey Toleco, Kevin SW Tan, Mark van der Giezen
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Cell Biology
    2. Neuroscience

    ATP8B1–TMEM30B Flippase Activity Maintains Stereocilia Lipid Asymmetry Required for Hearing

    Henry N De Hoyos, Sihan Li ... Jung-Bum Shin
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cell Biology
    2. Neuroscience

    Terminal Schwann Cells Regulate Presynaptic Vesicle Homeostasis but Not Neuromuscular Junction Integrity in Mice

    Hyun Kim, Seon-Yong Kim ... Young-Yun Kong
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology

    High basal autophagic activity in the brain revealed by systemic quantitative analysis using GFP-LC3-RFP mice

    Yuki Kanda, Tomoya Eguchi ... Noboru Mizushima
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology

    Mitochondrial-derived compartments buffer outer membrane protein load during acute mitochondrial adaptation

    Bo J Price, Sai Sangeetha Balasubramaniam, Adam L Hughes
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology

    Ferroptosis is executed through caspase-5 cleavage of gasdermin E in ovarian cancer cells

    Mahmuda Akter, Lei Sun ... Shuang Huang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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