Hanane Hadj-Moussa, Megan Ulusan ... Jonathan Houseley
Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.
Inflammatory activation of endothelial cells triggers Pink1-dependent mitophagy and mitochondrial formyl peptides release, which drives neutrophil recruitment and lung injury.
Krassimira A Garbett, James P Allen ... Richard C Sando
Long-term live imaging and tracking approaches reveal a coordination between excitatory and inhibitory synapse assembly, despite continual spatiotemporal dynamics.
Endosomes operate several exit routes that sort protein cargo and depend on pathway-specific associations of a PROPPIN with the responsible protein coat, such as the here identified CROP2, to support the departure of the cargo carriers.