Michael H Hayes, Elizabeth H Peuchen ... Daniel L Weeks
The equilibrium between solubility and aggregation of proteins in the nucleus is controlled by co-aggregates like RNA and the action of ATP as both an energy source and a destabilizing chemical agent.
Girish R Mali, Patricia L Yeyati ... Pleasantine Mill
Chaperoning defects in axonemal dynein subunits trigger proteostatic clearance of dynein motors opening up the possibility of trialling proteostasis modulators to treat the motile ciliopathy primary ciliary dyskinesia (PCD).
Wael Bazzi, Pierre B Cattenoz ... Angela Giangrande
Distinct hematopoietic waves interact via transcriptional cascades specific to embryonic hemocytes to ensure the proper immune response in Drosophila..
Yu Hsuan Carol Yang, Koichi Kawakami, Didier YR Stainier
A novel mode of organ innervation, whereby neurons establish connections with their targets before migrating away, was revealed by live imaging of the developing zebrafish pancreas.
Benjamin Schwarz, Dominik Hollfelder ... Ingolf Reim
A novel regulatory model for the diversification of cardiac cell subpopulations in Drosophila is established by linking epidermal growth factor signaling with differential activities of key transcription factors.
Lorriane Eley, Ahlam MS Alqahtani ... Deborah J Henderson
Identification of a novel source of progenitor cells that form arterial valve leaflets and that, when disrupted, can lead to bicuspid arterial valve, the most common human cardiac malformation.
The process of cytokinesis can allow cell lineages to intermix in mammalian epithelia, and cellular aspect ratio is a critical modulator of this behavior.
Franck Ladam, William Stanney ... Charles G Sagerström
TALE transcription factors bind different genomic motifs and function together with different protein partners at different stages of zebrafish embryogenesis.
