Xiao-Yong Li, Melissa M Harrison ... Michael B Eisen
Drosophila melanogaster embryos undergo a dramatic genomic transformation in the hour preceding gastrulation, as thousands of promoters and regulatory regions become biochemically distinct before they become active.
Young Seok Ju, Ludmil B Alexandrov ... Peter J Campbell
Identifying 1,907 mitochondrial somatic mutations from 1,675 tumor tissues provides new insights into the causes and effects of the mitochondrial genome mutations found in human cancers.
Arnaud R Krebs, Sophie Dessus-Babus ... Dirk Schübeler
Large numbers of DNA sequence variants comprehensively define how transcription factor binding sites and CG density preserve mammalian promoters from repression by DNA methylation.
Benoit Ballester, Alejandra Medina-Rivera ... Michael D Wilson
Combinatorial transcription factor binding shared by multiple species enriches for essential biological pathways and coincides with disease-causing regulatory DNA mutations.
Ines A Drinnenberg, Dakota deYoung ... Harmit Singh Malik
CenH3, the defining component of centromeres in almost all eukaryotes, was independently lost in four insect lineages that transitioned from monocentricity to holocentricity.