Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics

    Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

    Leslie M Turner, Bettina Harr
    The genomic regions that cause male hybrids between house mouse subspecies to have low fertility have been identified.
    1. Developmental Biology
    2. Genetics and Genomics

    Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition

    Xiao-Yong Li, Melissa M Harrison ... Michael B Eisen
    Drosophila melanogaster embryos undergo a dramatic genomic transformation in the hour preceding gastrulation, as thousands of promoters and regulatory regions become biochemically distinct before they become active.
    1. Developmental Biology
    2. Genetics and Genomics

    The rosetteless gene controls development in the choanoflagellate S. rosetta

    Tera C Levin, Allison J Greaney ... Nicole King
    The establishment of forward genetics in S. rosetta reveals the first gene known to be required for choanoflagellate multicellular development.
    1. Genetics and Genomics
    2. Cancer Biology

    Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

    Young Seok Ju, Ludmil B Alexandrov ... Peter J Campbell
    Identifying 1,907 mitochondrial somatic mutations from 1,675 tumor tissues provides new insights into the causes and effects of the mitochondrial genome mutations found in human cancers.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions

    Arnaud R Krebs, Sophie Dessus-Babus ... Dirk Schübeler
    Large numbers of DNA sequence variants comprehensively define how transcription factor binding sites and CG density preserve mammalian promoters from repression by DNA methylation.
    1. Genetics and Genomics

    Multi-species, multi-transcription factor binding highlights conserved control of tissue-specific biological pathways

    Benoit Ballester, Alejandra Medina-Rivera ... Michael D Wilson
    Combinatorial transcription factor binding shared by multiple species enriches for essential biological pathways and coincides with disease-causing regulatory DNA mutations.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Recurrent loss of CenH3 is associated with independent transitions to holocentricity in insects

    Ines A Drinnenberg, Dakota deYoung ... Harmit Singh Malik
    CenH3, the defining component of centromeres in almost all eukaryotes, was independently lost in four insect lineages that transitioned from monocentricity to holocentricity.