Browse our latest Genetics and Genomics articles

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    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

    Rebecca Warfvinge, Linda Geironson Ulfsson ... Göran Karlsson
    Single-cell analysis of CML patients bone marrow at diagnosis reveals coexistence of CD26-CD35+ healthy stem cells and CD26+CD35- CML stem cells, and how the ratio between these impacts TKI response.
    1. Genetics and Genomics

    DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

    Xiang Wang, Gan Shen ... Ying Shen
    DNAH3 is a novel pathogenic gene of male infertility and plays essential role in flagellar IDA assembly in humans and mice.
    1. Genetics and Genomics

    Perturbations in eIF3 subunit stoichiometry alter expression of ribosomal proteins and key components of the MAPK signaling pathways

    Anna Herrmannová, Jan Jelínek ... Leoš Shivaya Valášek
    eIF3, despite being a general translation initiation factor, functions in mRNA-specific regulation, having a profound impact on the synthesis and activation of the MAPK pathway components and ribosomal proteins.
    1. Cell Biology
    2. Genetics and Genomics

    Calcineurin inhibition enhances Caenorhabditis elegans lifespan by defecation defects-mediated calorie restriction and nuclear hormone signaling

    Priyanka Das, Alejandro Aballay, Jogender Singh
    Calcineurin inhibition has opposing effects on Caenorhabditis elegans lifespan and survival on pathogens via its role in the defecation motor program.
    1. Developmental Biology
    2. Genetics and Genomics

    Diverse somatic Transformer and sex chromosome karyotype pathways regulate gene expression in Drosophila gonad development

    Sharvani Mahadevaraju, Soumitra Pal ... Brian Oliver
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    Insights into early animal evolution from the genome of the xenacoelomorph worm Xenoturbella bocki

    Philipp H Schiffer, Paschalis Natsidis ... Maximilian J Telford
    A genome analysis of Xenoturbella bocki provides insights into the biology of this enigmatic marine worm and enhances our understanding of early bilaterian evolution.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Somatic mutation rates scale with time not growth rate in long-lived tropical trees

    Akiko Satake, Ryosuke Imai ... Masahiro Kasahara
    Long-lived tropical trees in Southeast Asia accumulate somatic mutations in a manner that is dependent on time, rather than growth rate.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    DGRPool, a web tool leveraging harmonized Drosophila Genetic Reference Panel phenotyping data for the study of complex traits

    Vincent Gardeux, Roel PJ Bevers ... Bart Deplancke
    The DGRPool web tool aggregates phenotyping data from the Drosophila Genetic Reference Panel, streamlining genetic association studies and offering new insights into genetic and phenotypic variation in complex traits.
    1. Genetics and Genomics
    2. Neuroscience

    Population clustering of structural brain aging and its association with brain development

    Haojing Duan, Runye Shi ... Jianfeng Feng
    Studies of heterogeneity in healthy brain aging reveal varying susceptibilities to aging and delayed development, which deepen aging-development understanding and promote prediction and diagnosis of cognitive decline and neurodegenerative diseases.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants

    Alon Avraham Ginatt, Maria Berihu ... Shiri Freilich
    Understanding metabolic interactions and successive cross-feeding in native microbiomes illuminates the mechanisms behind plant disease promotion and suppression, enhancing our ability to manipulate microbiomes toward specific functions of interest.