A MASLD mouse model reveals that gut-derived Gram-negative bacterial lipopolysaccharides promote hepatic lipid accumulation and acyloxyacyl hydrolase, a host lipase that degrades and inactivates lipopolysaccharides and mitigates MASLD.
Immune memory B cells in people with cystic fibrosis contain bacteria-specific sequences that could be used to make new treatments for life-threatening infections.
Disruption of RAS–p110α signalling in macrophages impairs both the initiation and resolution of inflammatory responses, revealing a critical regulatory role in immune function and inflammation control.
Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.
The established under-flow migration tracker (UFMTrack) framework allows for automated and scalable studies of immune cell interactions with and extravasation across endothelial monolayer under flow in vitro.
Eugenio Antonio Carrera Silva, Juliana Puyssegur, Andrea Emilse Errasti
Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and extracellular vesicles.
Graham L Barlow, Christian M Schürch ... Paul L Bollyky
A high-parameter, spatial analysis of the pancreata of individuals with type 1 diabetes reveals specific patterns of immune infiltration into islets of Langerhans, coordinated with changes in the surrounding tissue.
Hella Luksch, Felix Schulze ... Angela Rösen-Wolff
TNF signaling contributes significantly to pathology of constitutively active STING in murine STING-associated vasculopathy with onset in infancy disease.
