Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

    Jian Cui, Hua Li ... Congqing Wu
    Procoagulant microvesicles derived from ruptured immune cells fuel blood coagulation.
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s disease

    Rocio Vicario, Stamatina Fragkogianni ... Frédéric Geissmann
    A subset of Alzheimer disease patients carry mutant microglia somatic clones which promote neuro-inflammation.
    1. Immunology and Inflammation

    Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

    Sytse J Piersma, Shasha Li ... Wayne M Yokoyama
    A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.
    1. Immunology and Inflammation

    The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020

    João Paulo Portela Catani, Anouk Smet ... Thorsten U Vogel
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions

    Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cancer Biology
    2. Immunology and Inflammation

    Unraveling the power of NAP-CNB’s machine learning-enhanced tumor neoantigen prediction

    Almudena Mendez-Perez, Andres M Acosta-Moreno ... Esteban Veiga
    NAP-CNB, a machine learning platform, accurately identifies tumor neoantigens, where higher tumor expression correlates with optimal antitumor activity, and multiantigen vaccination enhances immune responses.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant

    Hiroyuki Yamamoto, Tetsuro Matano
    Attenuation of viral Nef-driven PI3 kinase signaling in B cells precedes the induction of neutralizing antibody responses against a difficult-to-neutralize simian immunodeficiency virus.
    1. Immunology and Inflammation

    A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

    Yan Qian, Qiannv Liu ... Pengyan Xia
    It is a new pattern of recognition between bacterial proteins and the host immune system during P. aeruginosa infection, producing a new virulence factor to inhibit the host's immune response.
    1. Immunology and Inflammation
    2. Medicine

    Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

    Ole Bæk, Tik Muk ... Duc Ninh Nguyen
    Reduced parenteral glucose during neonatal infection redirects hepatic metabolism to oxidative phosphorylation and gluconeogenesis, dampens systemic proinflammatory responses, and significantly enhances survival in preterm newborns.
    1. Immunology and Inflammation

    Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

    Alexander J Knights, Easton C Farrell ... Tristan Maerz
    Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.