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    1. Immunology and Inflammation

    T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells

    Josep Garnica, Patricia Sole ... Pere Santamaria
    T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis

    Stephanie Guillet, Tomi Lazarov ... Frédéric Geissmann
    Loss-of-function variants of human ACK1 and BRK kinase underlie systemic lupus erythematosus in young patients from multiplex families and disrupt the anti-inflammatory response of macrophages to apoptotic cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

    Luz Saavedra-Sanchez, Mary S Dickinson ... Jörn Coers
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity

    Hong Yu, Hiroshi Nishio ... Drew Pardoll
    Nrn1, a novel extracellular evolutionarily conserved molecule, impacts cellular electric and metabolic state and contributes to cell fate and immune response outcome.
    1. Immunology and Inflammation

    Development of a new genotype–phenotype linked antibody screening system

    Takashi Watanabe, Hikaru Hata ... Hidehiro Fukuyama
    A Golden Gate-based dual-expression vector enables rapid screening, which facilitates efficient isolation of high-affinity cross-reactive antibodies for therapeutic or diagnostic use and provides a crucial advance for pandemic preparedness.
    1. Medicine
    2. Immunology and Inflammation

    Inhibition on neutrophil extracellular traps by oligomeric procyanidins alleviate chemotherapy-induced chronic kidney injury via gut-kidney axis

    Yaqi Luan, Weiwei He ... Rong Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Chemokine expression profile of an innate granuloma

    Megan E Amason, Cole J Beatty ... Edward A Miao
    A successful innate granuloma requires CCR2 to organize the macrophage ring, and without CCR2, mice succumb to Chromobacterium violaceum infection.
    1. Immunology and Inflammation

    Autoimmunity: The epigenetic trajectory of type 1 regulatory T cells

    David P Turicek, Xiaoxiao Wan
    The epigenome of T follicular helper cells prepares them for conversion into type 1 regulatory T cells.
    Version of Record
    Insight
    1. Immunology and Inflammation

    Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice

    Puqiao Lian, Artemiy Kovynev ... Saskia Braber
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Medicine
    2. Immunology and Inflammation

    Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis

    Ben Higgins, Ioannis Simitsidellis ... Damian J Mole
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
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