During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.
Mohsen Khosravi-Maharlooei, Andrea Vecchione ... Megan Sykes
Functional analyses identify Tfh-like and Tph-like CD4+ T cells as drivers of a spontaneous autoimmune syndrome characterized by autoreactive B cells in human immune system mice.
Disruption of RAS–p110α signalling in macrophages impairs both the initiation and resolution of inflammatory responses, revealing a critical regulatory role in immune function and inflammation control.
A MASLD mouse model reveals that gut-derived Gram-negative bacterial lipopolysaccharides promote hepatic lipid accumulation and acyloxyacyl hydrolase, a host lipase that degrades and inactivates lipopolysaccharides and mitigates MASLD.
Immune memory B cells in people with cystic fibrosis contain bacteria-specific sequences that could be used to make new treatments for life-threatening infections.
Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.
Graham L Barlow, Christian M Schürch ... Paul L Bollyky
A high-parameter, spatial analysis of the pancreata of individuals with type 1 diabetes reveals specific patterns of immune infiltration into islets of Langerhans, coordinated with changes in the surrounding tissue.
The established under-flow migration tracker (UFMTrack) framework allows for automated and scalable studies of immune cell interactions with and extravasation across endothelial monolayer under flow in vitro.
