Rémi Porte, Rita Silva-Gomes ... Alberto Mantovani
Long Pentaxin 3 is highly expressed by non-hematopoietic cells during Streptococcus pneumoniae invasive infections and regulates polymorphonuclear neutrophils' recruitment through interaction with P-selectin which damps inflammation-associated tissue damage and pneumococcal systemic dissemination.
Rafaela M Guimarães, Conceição E Aníbal-Silva ... Thiago M Cunha
CX3CR1-signaling in sensory ganglia macrophages mediates their proliferation/activation, as well as the production of pro-inflammatory mediators that contribute to neuropathic pain.
Sharon A McGrath-Morrow, Jarrett Venezia ... Alan L Scott
A pre-clinical model of E. coli pneumonia reveals attenuated dynamics of MHCII-expressing mononuclear cells in neonatal lung associated with elevated susceptibility to bacterial pneumonia.
Minato Hirano, Gaddiel Galarza-Muñoz ... Mariano A Garcia-Blanco
RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.
Pedro P Cunha, Eleanor Minogue ... Randall S Johnson
Oxygen levels at the time of T cell activation are major determinants of function, even when T cells are subsequently expanded in high levels of oxygen.
Sindhu Mohandas, Prasanna Jagannathan ... RECOVER Mechanistic Pathways Task Force
Immune dysregulation is thought to be a hallmark of long COVID or PASC but there is a need for understanding the underlying mechanisms which drive the disease progression.
Magdalena L Russell, Noah Simon ... Frederick A Matsen IV
Local sequence context, length, and GC nucleotide content in both directions of the trimming site, together, are highly predictive of V(D)J trimming probabilities for both TR and IG adaptive immune receptor loci.
