Browse our latest Immunology and Inflammation articles

A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.

The development and functionalities of invariant natural-killer T cells are dependent upon their cell-intrinsic ACC1-mediated de novo fatty acid synthesis, which greatly affect outcomes of allergic asthma.

A novel therapy for a common blinding retinal disease uses an innovative CCR1 blocking-based strategy.

The bicontinuous nanospheres platform enables dual encapsulation and in vivo activation of lipid and protein antigen-specific T cells, resulting in enduring lipid depots for sustained immune responses.

PLWH over a decade of ART showed a significant reshaping of the function and expression of inhibitory receptors across the CD8+ T cell landscape, ultimately leading to a decrease of CD107a TIGIT HIV-1-specific CD8+ T cells recovered by TIGIT blockade.

Identification of human DNA sites differentially methylated with aging across six different primary immune cells suggests that the sensing of hypoxia drives the epigenetic clock.

Identification of transcriptional changes in the hypothalamus during Influenza A virus infection enhances our understanding of mechanisms underlying long-lasting neurological disturbances, potentially informing future therapeutic interventions and improving patient outcomes.

SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.

Comparing the inflammatory proteome of healthy Tanzanian and Dutch adults highlights a pro-inflammatory phenotype and metabolic differences in Tanzanians, with the potential role of food-derived metabolites in driving inflammation.