Browse our latest Microbiology and Infectious Disease articles

Like two peas in a pod but not exactly alike, similar molecules targeting the same bacterial protein behave differently, requiring systems biology and target deconvolution to gain better comprehension.

A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and displays the potential of drugs to reverse these defects.

Antigenic drift in influenza’s major surface proteins, hemagglutinin and neuraminidase, contributes to variability in epidemic magnitude across seasons but is less influential than subtype interference in shaping annual outbreaks.

Isoniazid resistance in Mycobacterium tuberculosis is linked to higher rifampicin tolerance, necessitating evaluation and potential adjustment of treatment regimens to combat emerging multi-drug resistant variants.

Dimension reduction and machine learning tools were used to identify novel associations between the HIV reservoir and the immune systems of people with HIV.

The genetic 'fossil record' of a retroviral lineage over >25 million years of evolution reveals the profound consequences of an ancient recombination event on viral replication mechanisms and genome structure, and identifies an ancient interspecies viral transmission.

The timescale dependence of d_N/d_S in bacteria is better explained by adaptive than purifying dynamics, suggesting comparative genomics can underestimate past adaptation.