Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis

    Xufeng Xie, Xi Chen ... Yongguo Cao
    Gut dysbiosis is involved in severe leptospirosis that is related to translocated microbiota-derived lipopolysaccharide.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease

    Kejia Zhang, Patrick Eldin ... Dragony Fu
    SARS-CoV-2 infection reduces the intracellular levels of a human tRNA modification enzyme and alters host tRNA modification profiles.
    1. Microbiology and Infectious Disease

    Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses

    Cody J. Warren, Arturo Barbachano-Guerrero ... Sara L. Sawyer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Convincing
    1. Microbiology and Infectious Disease

    A modified BCG with depletion of enzymes associated with peptidoglycan amidation induces enhanced protection against tuberculosis in mice

    Moagi Tube Shaku, Peter K Um ... Bavesh D Kana
    The new vaccine candidate for tuberculosis displays superior protection against disease when compared the currently available vaccine, and can potentially provide new options for global childhood vaccination programs.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages

    Timothy A Bates, Mila Trank-Greene ... Fikadu G Tafesse
    ESAT-6, a virulence factor of Mycobacterium tuberculosis, dimerizes at neutral pH and transitions to oligomers under acidic pH similar to that of lysosome, helping the bacterium evade host defense mechanisms.
    1. Microbiology and Infectious Disease

    The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

    João Paulo Portela Catani, Anouk Smet ... Thorsten U Vogel
    N2 neuraminidases from human H3N2 viruses from 2009 until 2017 can be subdivided into four antigenic groups, with amino acid substitutions near the catalytic site more likely impacting neuraminidase inhibition.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Secreted dengue virus NS1 from infection is predominantly dimeric and in complex with high-density lipoprotein

    Bing Liang Alvin Chew, AN Qi Ngoh ... Dahai Luo
    Molecular architecture of the secreted NS1 dimer from dengue virus infection in complex with a high density lipoprotein particle.
    1. Microbiology and Infectious Disease

    A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

    Swagata Bose, Satya Ranjan Sahu ... Narottam Acharya
    A detailed characterizations of EDTA-treated Candida albicans cells both in vitro and pre-clinical models led to discovery of a potential live whole-cell vaccine against fungal infections.