A model is proposed to estimate the nuclear export rate of mRNAs produced in a transcription burst, using the spatial distribution of mRNAs determined by single-molecule RNA imaging.
An optimized cytosine base editing system for Leishmania species improves editing efficiency, reduces toxicity, and ensures stable guide expression, enabling scalable loss-of-function screening and efficient creation of functional mutants.
Extremely early antiretroviral therapy during HIV-1 subtype C infection leads to faster decline in genome-intact viruses, reduced genetic complexity, and immune escape, and may enhance reservoir clearance with additional interventional strategies.
Benita Martin-Castaño, Patricia Diez-Echave ... Julio Galvez
Biomarkers of COVID-19 severity identified in nasopharyngeal and faecal microbiota could improve prognostic accuracy and treatment strategies for severe cases.
Vivian C Salgueiro-Toledo, Jorge Bertol ... Rafael Prados-Rosales
Genetic, ultrastructural, multi-omics, and biochemical tools reveal VirR as a central scaffold in Mycobacterium tuberculosis cell envelope remodelling, critical for extracellular vesicle production.
The observation that an additional vaccine dose provides protection against Omicron variant reinfection in previously vaccinated and infected individuals will help guide future COVID-19 vaccination policies in China and globally.
Manuela C Aguirre-Botero, Olga Pacios ... Rogerio Amino
A late-neutralizing monoclonal antibody targeting the major surface antigen of plasmodial sporozoites impairs the fitness of intracellular parasites, offering mechanistic insights to guide the development of potent anti-malaria antibodies.
