Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    Serial ‘deep-sampling’ PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected human, macaque, and canine hosts, and allows accurate monitoring of parasite load following treatment

    Brooke E White, Carolyn L Hodo ... Rick L Tarleton
    A vastly improved PCR-based approach provides a long-sought test of cure and parasite load monitoring tool for Chagas disease.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

    Aleksandra Prochera, Anoohya N Muppirala ... Meenakshi Rao
    Genetic depletion of enteric glia in vivo disrupts antimicrobial peptide secretion by Paneth cells to change fecal microbial composition but does not broadly alter other intestinal programs.
    1. Microbiology and Infectious Disease

    Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

    Carley N Gray, Manickam Ashokkumar ... Michael Emerman
    A block to more potent and specific release of HIV from latency has been identified as a subunit of the Integrator complex, which may aid strategies for HIV cure.
    1. Microbiology and Infectious Disease

    Screening Envelope Genes Across Primate Genomes Reveals Evolution and Diversity Patterns of Endogenous Retroviruses

    Saili Chabukswar, Nicole Grandi ... Enzo Tramontano
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    FtsK is critical for the assembly of the unique divisome complex of the FtsZ-less Chlamydia trachomatis

    McKenna Harpring, Junghoon Lee ... John V Cox
    The novel divisome complex of Chlamydia trachomatis contains elements of the divisome and elongasome from other bacteria, and it requires the chromosomal translocase, FtsK, for its assembly.
    1. Microbiology and Infectious Disease

    Linalool combats Saprolegnia parasitica infections through direct killing of microbes and modulation of host immune system

    Tao Tang, Weiming Zhong ... Zhipeng Gao
    Linalool demonstrates dual antimicrobial and immunomodulatory actions against Saprolegnia parasitica.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Control of pili synthesis and putrescine homeostasis in Escherichia coli

    Iti Mehta, Jacob B Hogins ... Larry Reitzer
    Putrescine has a homeostatic network that controls pili synthesis and energy metabolism.
    1. Microbiology and Infectious Disease
    2. Epidemiology and Global Health

    Estimation of Rotavirus Vaccine Effectiveness Based on Whole Genome Sequences

    Jiye Kwon, Jose Jaimes ... Virginia E Pitzer
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages

    Ainhoa Arbués, Sarah Schmidiger ... Damien Portevin
    Genetically diverse Mycobacterium tuberculosis complex strains induce a gamut of human granulomatous responses in vitro, with a role for IL-1β in aggregate formation.
    1. Microbiology and Infectious Disease

    Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae

    Yue Sun, Jingwei Li ... Xin Deng
    The genome-wide transcriptional regulatory network in Pseudomonas syringae demonstrates the regulatory diversity and functional pathways.