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    1. Microbiology and Infectious Disease

    Helicase Loading: A back-up mechanism for replication

    Godefroid Charbon, Anders Løbner-Olesen
    A protein called PriC allows DNA replication to proceed in Escherichia coli when the complex that usually initiates this process is compromised.
    Version of Record
    Insight
    1. Microbiology and Infectious Disease

    A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics

    Gabriele Baniulyte, Joseph T Wade
    An upstream open-reading frame in Escherichia coli regulates expression of the downstream genes in response to diverse translation stresses.
    1. Microbiology and Infectious Disease

    Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC

    Ryusei Yoshida, Kazuma Korogi ... Tsutomu Katayama
    PriC provides a bypass mechanism for compromised helicase loading at the origin of the Escherichia coli chromosome, which ensures the robustness of the chromosome replication initiation.
    1. Microbiology and Infectious Disease

    Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria

    Le Zhang, Yunpeng Guan ... Dayong Jin
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach

    Nisheeth Agarwal, Himanshu Gogoi ... Bappaditya Dey
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    Type I interferon responses contribute to immune protection against mycobacterial infection

    Andrea Szydlo-Shein, Blanca Sanz-Magallón Duque de Estrada ... Gillian S Tomlinson
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA-assisted uptake and ribosomal protein RplL sensitivity

    Jingbo Kan, Adrian Morales-Amador ... Sean F Brady
    Oxydifficidin presents potent activity against multidrug-resistant Neisseria gonorrhea with a new mode of action, which opens a new avenue for potentially addressing antibiotic resistant gonorrhea.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani

    Supratim Pradhan, Dhruba Dhar ... Budhaditya Mukherjee
    Nutritional adaptations in Leishmania donovani enable persistent antimony resistance and reduced Amphotericin-B effectiveness by selectively exploiting host lipids and limiting cholesterol mobilization.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

    Sihui Cai, Jie Zhou ... Jun Cui
    IFN-β-induced WTAP phase transition bridges STAT1 and MTC, which orchestrates m6A dynamics on ISG mRNAs to suppress excessive immune response and sustain immune homeostasis.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia

    Marc-Antoine Guery, Sukai Ceesay ... Antoine Claessens
    Household clustering and seasonal parasite dynamics highlight the need to target asymptomatic carriers for community-based malaria elimination strategies.
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