The molecular, cellular, and spatial heterogeneity of adult human spinal cord serve as an important resource to explore the mechanisms underlying spinal cord physiology and diseases.
A generative-model-based, unsupervised learning toolbox for characterizing oscillatory bursting and brain network dynamics in univariate or multivariate time series.
Nuria Martin Flores, Marina Podpolny ... Patricia C Salinas
The Wnt antagonist DKK3 is a key regulator of excitatory and inhibitory synapses, and its downregulation in the hippocampus restores synaptic connectivity and memory in an Alzheimer's disease mouse model.
The large range of timescales empirically observed in neural circuits can be naturally explained when neural assemblies of heterogeneous size are recurrently coupled, empowering the neural circuits to efficiently process complex time-varying input signals.
Harsh N Hariani, A Brynn Algstam ... Timothy S Balmer
Unipolar brush cells subtypes, classified by their excitatory or inhibitory response to glutamate, form circuits with one another that may enhance the capacity of the cerebellum to transform input signals.
Xingyu Ding, Sean Froudist-Walsh ... Xiao-Jing Wang
Large-scale modeling of the mouse brain revealed that working memory is modular and determined by long-range cell type-specific connections, thereby providing a framework to interpret brain-wide recordings during cognition.
