Browse our latest Neuroscience articles

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    1. Computational and Systems Biology
    2. Neuroscience

    High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

    George A Spirou, Matthew Kersting ... Paul B Manis
    Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.
    1. Neuroscience
    2. Computational and Systems Biology

    A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics

    Yuri Elias Rodrigues, Cezar M Tigaret ... Romain Veltz
    A computational model of glutamatergic synapse uncovers a new plasticity rule which takes into account the various experimental conditions.
    1. Cell Biology
    2. Neuroscience

    Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases

    Hanako Hagio, Wataru Koyama ... Masahiko Hibi
    Functional assays using zebrafish reveal that various microbial channelrhodopsins, guanylyl cyclase rhodopsin, and photoactivated adenylyl cyclases function as potent optogenetic tools, effectively controlling neural activity and cardiac function in zebrafish.
    1. Cell Biology
    2. Neuroscience

    Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells

    Hanako Hagio, Wataru Koyama ... Masahiko Hibi
    Animal G-protein-coupled bistable rhodopsins can regulate Gq- and Gi-mediated signaling in a light-dependent manner in neurons and cardiomyocytes, making them useful for analyzing the roles of GPCR signaling in vivo.
    1. Neuroscience

    Novelty and uncertainty differentially drive exploration across development

    Kate Nussenbaum, Rebecca E Martin ... Catherine A Hartley
    From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.
    1. Neuroscience

    Variability of visual field maps in human early extrastriate cortex challenges the canonical model of organization of V2 and V3

    Fernanda Lenita Ribeiro, Ashley York ... Alexander Puckett
    The representation of the retina in early visual cortex shows that human brains have diverse functional organizations, raising questions about developmental mechanisms for visual map formation and how reliably these can be described by average templates.
    1. Neuroscience

    Per-ischemic changes in penumbral blood supply and its microscopic distribution

    Nina K. Iversen, Eugenio Gutierréz Jimenéz ... Leif Østergaard
    Not revised
    Reviewed Preprint v1
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    • Incomplete
    1. Neuroscience

    Targeted memory reactivation in human REM sleep elicits detectable reactivation

    Mahmoud EA Abdellahi, Anne CM Koopman ... Penelope A Lewis
    Sound cues that were associated with memories during wake elicit memory reactivations when replayed to human participants during rapid eye movement sleep, those memory reactivations are identifiable by machine learning models that directly relate electroencephalography patterns of wake and sleep.
    1. Neuroscience

    No evidence from complementary data sources of a direct glutamatergic projection from the mouse anterior cingulate area to the hippocampal formation

    Lilya Andrianova, Steliana Yanakieva ... Michael T Craig
    A combination of anterograde and retrograde anatomical-tracing methods failed to provide evidence of a recently described projection from the anterior cingulate area to the hippocampus.
    1. Neuroscience

    Cytoarchitectonic, receptor distribution and functional connectivity analyses of the macaque frontal lobe

    Lucija Rapan, Sean Froudist-Walsh ... Nicola Palomero-Gallagher
    3D atlas of the macaque frontal lobe, based on the novel quantitative parcellation, integrates anatomical, neurochemical, and functional connectivity data.