Browse our latest Neuroscience articles

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    1. Cell Biology
    2. Neuroscience

    High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

    Haining Zhong et al.
    A high-fidelity and efficient strategy to use CRISPR/Cas9 to reversibly insert large DNA fragments into somatic cells to label or modify endogenous proteins for research and, in the future, for gene therapy.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding et al.
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
    1. Developmental Biology
    2. Neuroscience

    Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons

    Eljo Van Battum et al.
    3D imaging and time-lapse video-microscopy show that the PlexinB2 receptor controls the tempo of granule cell differentiation and sets the pace of their migration in mouse cerebellum.
    1. Neuroscience

    Attenuated dopamine signaling after aversive learning is restored by ketamine to rescue escape actions

    Mingzheng Wu et al.
    Interconnected ventral tegmental area and medial prefrontal cortex circuits causally link dopamine dynamics, aversive learning, and the effects of a promising rapidly acting antidepressant ketamine.
    1. Neuroscience

    Antidepressants: Where ketamine and dopamine collide

    David J Marcus, Michael R Bruchas
    Ketamine strengthens connections between two brain regions that are involved in the production and regulation of dopamine, which may explain how the drug can alleviate depression.
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    1. Developmental Biology
    2. Neuroscience

    Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway

    Shu-Min Chou et al.
    Kv1.1 potassium channels regulate postnatal neurogenesis in the hippocampus via increasing the membrane excitability that activates the TrkB signaling pathway in a cell-autonomous manner.
    1. Neuroscience

    Working memory gates visual input to primate prefrontal neurons

    Behrad Noudoost et al.
    Visual input to prefrontal cortex preferentially targets neurons with both sensory and motor properties, and the synaptic efficacy of these inputs is facilitated by working memory.
    1. Developmental Biology
    2. Neuroscience

    R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners

    Jessica Douthit et al.
    R7 photoreceptors require the endosomal protein Lost and Found to form stable connections only when this protein is also present in neurons that are synaptic partners of R7.