Human midbrain organoids provide a foundation for the development of patient-specific preclinical models to support personalized therapeutic approaches and enable evaluation of disease mechanisms and therapeutic strategies in human context.
Kenji J Nishimura, Denisse Paredes ... Michael R Drew
Chemogenetic and in vivo recording approaches reveal how persistent hyperactivity in the posterior paraventricular thalamus promotes sensitization of fear responses to unlearned threats after stress exposure.
