Marc E Normandin, Pedro M Ogallar ... Isabel A Muzzio
Stable and dynamic prelimbic neurons preserve threat-generalization gradients despite ensemble turnover, supporting enduring representations of stimulus significance rather than freezing.
Kristopher T Jensen, Peter T Doohan ... Timothy E Behrens
Recently discovered sequence representations in prefrontal cortex can be combined with the ubiquitous principle of neural attractor dynamics to support planning in complex environments.
Violations of strong memory-based predictions trigger a cascade of changes in cognitive control, attention, and arousal, with differential impacts on the encoding of unexpected information into memory.
Human forebrain organoids reveal that amyloid-driven microglia recruit killer T cells via CCL5, forming a self-amplifying neuroinflammatory loop targetable by CCR5 or CXCR3 blockade.
In mammalian neocortex, opposing Krüppel-like factor (KLF) transcription factors first activate and then repress a genetic program related to axon outgrowth, potentially contributing to loss of cortical axon outgrowth in the adult.
