Browse our latest Neuroscience articles

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    1. Neuroscience

    A visual sense of number emerges from divisive normalization in a simple center-surround convolutional network

    Joonkoo Park, David E Huber
    A set of canonical computational principles implemented in a simple feedforward neural network naturally gives rise to the network's sensitivity to numerosity and its illusory effects, providing an explanation for the ubiquity of the number sense in the animal kingdom.
    1. Neuroscience

    Phorbolester-activated Munc13-1 and ubMunc13-2 exert opposing effects on dense-core vesicle secretion

    Sébastien Houy, Joana S Martins ... Jakob Balslev Sørensen
    The priming protein ubMunc13-2 and Synaptotagmin-7 cooperate with phorbolesters/diacylglycerol to stimulate vesicle priming in adrenal chromaffin cells, whereas phorbolesters/diacylglycerol interacting with Munc13-1 inhibit vesicle fusion, which identifies opposing functions of these two Munc13 proteins.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Neurotransmission: Unmasking a two-faced protein

    Ivan Maslov, Jelle Hendrix
    Single-molecule fluorescence spectroscopy and molecular dynamics simulations illuminate the structure and dynamics of PSD-95, a protein involved in neural plasticity.
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    1. Neuroscience

    Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis

    Majd Abdallah, Gaston E Zanitti ... Demian Wassermann
    A comprehensive meta-analysis of the neuroimaging literature reveals that the lateral prefrontal cortex of humans is mainly organized along its rostrocaudal axis according to a unimodal-to-transmodal pattern of network connectivity and a concrete-to-abstract axis of functional associations.
    1. Neuroscience

    Foveal vision anticipates defining features of eye movement targets

    Lisa M Kroell, Martin Rolfs
    Before a saccadic eye movement to a location in the visual periphery, human observers' foveal vision becomes more sensitive to the features defining the eye movement target, anticipating information that will soon be fixated in a retinotopic reference frame.
    1. Neuroscience

    Balance between breadth and depth in human many-alternative decisions

    Alice Vidal, Salvador Soto-Faraco, Rubén Moreno-Bote
    A novel experimental paradigm investigating how humans manage limited search capacity over many alternatives reveals close-to-optimal behaviours and identifies heuristics used to minimize computation with little impact on performance.
    1. Neuroscience

    Disrupted-in-schizophrenia-1 is required for normal pyramidal cell–interneuron communication and assembly dynamics in the prefrontal cortex

    Jonas-Frederic Sauer, Marlene Bartos
    In a mouse model of psychiatric illness, the neuronal network of the medial prefrontal cortex is characterized by reduced activity levels of interneurons, impaired gamma oscillations, and altered activation of cell assemblies.
    1. Neuroscience

    Higher-order unimodal olfactory sensory preconditioning in Drosophila

    Juan Martinez-Cervantes, Prachi Shah ... Isaac Cervantes-Sandoval
    Drosophila flies infer value to olfactory stimuli based on the previously repeatedly presented associative structure between two odorants.
    1. Neuroscience

    Deep learning-based feature extraction for prediction and interpretation of sharp-wave ripples in the rodent hippocampus

    Andrea Navas-Olive, Rodrigo Amaducci ... Liset M de la Prida
    A new method is described to identify sharp-wave ripples from the rodent hippocampus with deep learning techniques, which may help to identify and characterize previously undetected physiological events.
    1. Neuroscience

    Robust cone-mediated signaling persists late into rod photoreceptor degeneration

    Miranda L Scalabrino, Mishek Thapa ... Greg D Field
    The retina compensates for rod death and deteriorating cones to retain high-fidelity visual signaling to the brain.