Browse our latest Neuroscience articles

Newly identified roles for the kinesin-1 light chain subunit KLC4 in patterning developing axon arbors, regulating microtubule dynamics and influencing behavior of larval and adult zebrafish.

A comprehensive analysis of Tensin3 function in oligodendrogenesis links the fields of transcriptional control in oligodendrocyte lineage cells with morphogenetic changes and integrin signaling mediated cell survival.

Conditional knockout mice revealed that oxytocin secretion from the paraventricular hypothalamic nucleus suppresses hyperphagic obesity partly via the oxytocin receptor expressed in the arcuate hypothalamic nucleus.

The activation of defence brain circuits drives decisions to help conspecifics under threat.

Neuronal glycolysis to restore energy consumed by ion movements is activated by engagement of the Na⁺/K⁺ pump, either directly by Na⁺ influx or indirectly, when Ca²⁺ influx is converted to Na⁺ accumulation by Na⁺/Ca²⁺ exchange.

A genetic manipulation of the Nrxn1/3^SS4+-Cbln1/2 complex reveals this signaling pathway has no role in synapse formation but functions to shape the NMDAR- and AMPAR-content at multiple types of synapses with distinct facets in diverse circuits.

Pre-existing variability in the regulation of non-rapid eye movement sleep predicts resilience to social-defeat stress.

A combination of genetic, electrophysiological, and modeling approaches reveals that presynaptic Rac1 is a key molecule that controls synaptic strength and plasticity by regulating the synaptic vesicle cycle steps controlling the number of fusion competent synaptic vesicles.

Single-cell RNA-sequencing unraveled cell subtype-specific transcriptomic changes in both injured and uninjured primary sensory neurons after nerve injury and demonstrated transcriptomic sexual dimorphism.

A combination of single molecule fluorescence with DMD simulations and disulfide mapping resolved the multistate structural landscape of the PSG supramodule from PSD-95, which explains how interdomain interactions within PSD-95 enable PDZ3 binding of the critical synaptic adhesion protein neuroligin.