Browse our latest Neuroscience articles

Page 221 of 599
    1. Genetics and Genomics
    2. Neuroscience

    Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

    Xinrui L Zhang, William C Spencer ... Evan S Deneris
    Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.
    1. Cell Biology
    2. Neuroscience

    The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus

    Natasha M Puri, Giovanna R Romano ... Roshanak Irannejad
    Dopamine D1 receptor signaling from the Golgi apparatus in murine striatal medium spiny neurons is regulated by monoamine transporter OCT2.
    1. Neuroscience

    Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

    Vasiliki-Ilya Gargareta, Josefine Reuschenbach ... Hauke B Werner
    Comparing humans and mice, the protein composition of central nervous system myelin and the transcriptional profiles of myelin-producing oligodendrocytes are largely similar with respect to abundant structural myelin constituents but show divergent expression of a range of other distinct genes.
    1. Genetics and Genomics
    2. Neuroscience

    Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression

    Hyojin Kim, Eric B Gao ... Benjamin D Philpot
    Normalizing Tcf4 expression during early postnatal development improves behavioral outcomes in Pitt-Hopkins syndrome (PTHS) model mice, suggesting that genetic therapies are feasible in individuals with PTHS.
    1. Neuroscience

    Widespread nociceptive maps in the human neonatal somatosensory cortex

    Laura Jones, Madeleine Verriotis ... Maria Fitzgerald
    Widespread somatosensory cortical activation following a single localised skin breaking procedure indicates a diffuse pain map in the human infant brain.
    1. Neuroscience

    One-shot generalization in humans revealed through a drawing task

    Henning Tiedemann, Yaniv Morgenstern ... Roland W Fleming
    Humans are able to generate a complete category of varied objects from just one exemplar shape, identifying and utilizing its most distinctive parts to create a coherent group, even for other observers.
    1. Cell Biology
    2. Neuroscience

    A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling

    Chi-Hong Wu, Vedakumar Tatavarty ... Gina G Turrigiano
    Activity-dependent bidirectional changes in phosphorylation of the autism-associated scaffold protein Shank3 are essential for the expression of homeostatic synaptic plasticity.
    1. Cell Biology
    2. Neuroscience

    MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

    Andrea Toledo, Mathieu Letellier ... Olivier Thoumine
    MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.
    1. Neuroscience

    Oxytocin neurons mediate the effect of social isolation via the VTA circuits

    Stefano Musardo, Alessandro Contestabile ... Camilla Bellone
    Oxytocin neurons in the paraventricular nucleus of the hypothalamus mediate the increased sociability as a consequence of acute social isolation during adolescence via ventral tegmental area circuits.
    1. Neuroscience

    Distinct representations of body and head motion are dynamically encoded by Purkinje cell populations in the macaque cerebellum

    Omid A Zobeiri, Kathleen E Cullen
    The transformation of multiple streams of sensory information into an estimate of body motion occurs between the cerebellum and deep cerebellar nucleus to ensure postural and perceptual stability.