Browse our latest Neuroscience articles

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    1. Neuroscience

    Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice

    Amol Bhandare, Joseph van de Wiel ... Nicholas Dale
    Recordings from brainstem nuclei involved in chemosensory regulation of breathing in awake freely behaving mice show different complementary types of neuronal responses to hypercapnia in the retrotrapezoid nucleus and the rostral medullary raphe.
    1. Neuroscience

    Precise and stable edge orientation signaling by human first-order tactile neurons

    Vaishnavi Sukumar, Roland S Johansson, J Andrew Pruszynski
    Individual human first-order tactile neurons, those that innervate the mechanoreceptors in the skin, can signal information about edge orientation differences at the limit of what people can feel and across a broad range of speeds relevant for real-world hand use.
    1. Neuroscience

    Hippocampus: Connecting to the long axis

    Bryan A Strange
    New study reveals how various regions of the human cortex connect to the hippocampus along its longer anterior-posterior axis, shedding light on the way this structure is functionally organized.
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    1. Neuroscience

    Sampling motion trajectories during hippocampal theta sequences

    Balazs B Ujfalussy, Gergő Orbán
    The rodent brain represents uncertainty associated with short-term predictions during naturalistic navigation tasks sequentially by sampling hypothetical future trajectories in every ~100 ms, corresponding to successive theta cycles.
    1. Neuroscience

    Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

    Ioannis Zalachoras, Eva Ramos-Fernández ... Carmen Sandi
    The capacity to sustain effort to obtain rewards over time depends on the levels of the antioxidant glutathione in the nucleus accumbens - a brain region critical for motivated behavior - and can be boosted with a nutritional intervention (N-acetylcysteine).
    1. Neuroscience

    New insights into anatomical connectivity along the anterior–posterior axis of the human hippocampus using in vivo quantitative fibre tracking

    Marshall A Dalton, Arkiev D'Souza ... Fernando Calamante
    The results reported here provide new and foundational insights into the neural architecture that underpins hippocampal dependent memory systems in the human brain by providing detailed maps that show how different cortical areas anatomically connect within the hippocampus.
    1. Neuroscience

    NaV1.1 is essential for proprioceptive signaling and motor behaviors

    Cyrrus M Espino, Cheyanne M Lewis ... Theanne N Griffith
    The voltage-gated sodium channel Nav1.1 is identified as an essential component of the proprioceptive transmission machinery that is required in vivo for normal motor behavior.
    1. Neuroscience

    Sonic hedgehog-dependent recruitment of GABAergic interneurons into the developing visual thalamus

    Rachana Deven Somaiya, Katelyn Stebbins ... Michael A Fox
    Retinal ganglion cell axons release the morphogen sonic hedgehog which signals through astrocytes to induce the migration of inhibitory interneurons into the developing visual thalamus.
    1. Neuroscience

    Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons

    Viktor J Oláh, Nigel P Pedersen, Matthew JM Rowan
    Artificial neural networks can faithfully recapitulate realistic neuronal behavior with dramatically accelerated simulation runtimes, empowering accessible large-scale realistic network simulations.
    1. Neuroscience

    Contextual effects in sensorimotor adaptation adhere to associative learning rules

    Guy Avraham, Jordan A Taylor ... Samuel D McDougle
    Core associative learning phenomena that are observed in studies of eyeblink conditioning are also observed in sensorimotor adaptation, pointing to a common framework for these distinct cerebellar-dependent motor learning processes.