Browse our latest Neuroscience articles

Page 238 of 599
    1. Neuroscience

    Pupil diameter is not an accurate real-time readout of locus coeruleus activity

    Marine Megemont, Jim McBurney-Lin, Hongdian Yang
    Pupil diameter cannot accurately predict spiking activity in the locus coeruleus on a moment-by-moment basis, and exhibited large fluctuations to identical stimulation in the LC.
    1. Developmental Biology
    2. Neuroscience

    Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

    Hui Yu, Marcelo Rubinstein, Malcolm J Low
    Single-cell transcriptomic analyses of hypothalamic POMC neurons performed at seven developmental ages revealed marked cellular heterogeneity and divergent developmental pathways into alternative neuronal phenotypes that lack POMC.
    1. Neuroscience

    Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

    Joshua M Tworig, Chandler J Coate, Marla B Feller
    During development, lateral processes of retinal Müller glia are highly motile, and this motility persists when retinal waves and calcium transients are blocked, suggesting that Müller glial morphology is established independent of neuronal activity.
    1. Neuroscience

    Most primary olfactory neurons have individually neutral effects on behavior

    Tayfun Tumkaya, Safwan Burhanudin ... Adam Claridge-Chang
    Of the 50 primary olfactory channels in vinegar flies, only 10 drive avoidance or approach behavior when activated by themselves, indicating that most olfactory responses are multi-channel responses that follow complex combination rules.
    1. Neuroscience

    Dynamic decision policy reconfiguration under outcome uncertainty

    Krista Bond, Kyle Dunovan ... Timothy Verstynen
    A suspected change in action-outcome contingencies evokes a stereotyped response in the processes underlying a decision, resulting in a slow exploratory decision policy that gradually shifts to an exploitative policy as the environment remains stable.
    1. Neuroscience

    ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal

    Elham Jalalvand, Jonatan Alvelid ... Ilaria Testa
    Expansion microscopy combined with light-sheet and STED microscopy elucidated the spatial organization and subcellular composition of two distinct GABAergic CSF-c neuronal subtypes in the lamprey spinal cord.
    1. Neuroscience

    Dissociation of impulsive traits by subthalamic metabotropic glutamate receptor 4

    Lukasz Piszczek, Andreea Constantinescu ... Wulf Haubensak
    Metabotropic glutamate receptors modulate impulse control by the subthalamic nucleus, dissociating trait impulsivity from basal ganglia motor function.
    1. Medicine
    2. Neuroscience

    Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum

    Alex Reichenbach, Rachel E Clarke ... Zane B Andrews
    Hunger-sensitive AgRP neurons must sense changes in calorie availability to transmit metabolic information into dopamine release in the NAc and dorsal striatum, albeit over different time frames, to increase motivated food reward seeking.
    1. Computational and Systems Biology
    2. Neuroscience

    The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2

    Marieke MB Hoekstra, Maxime Jan ... Paul Franken
    Sleep-wake patterns, together with a suprachiasmatic nuclei-independent circadian factor, are necessary and sufficient to maintain high-amplitude nychthemeral rhythms in PERIOD-2.
    1. Neuroscience

    Synaptic memory requires CaMKII

    Wucheng Tao, Joel Lee ... Roger A Nicoll
    Physiology studies demonstrate that CaMKII is a molecular storage device.