Maria-Daniela Cirnaru, Sicheng Song ... Michelle E Ehrlich
RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.
Fluctuations of spectral power in large-scale cortical networks shape behavior in a perceptual decision-making task through arousal-linked and arousal-independent mechanisms.
Inhibitory cerebellar feedback to the inferior olive is central to computational models of learning, but novel targets of these neurons identified here expand their potential roles.
Anika Stockert, Michael Schwartze ... Sonja A Kotz
With unique lesion-informed tractography, left hemisphere temporo-cerebellar structural connectivity has been established, supporting rapid auditory transmission and cortical functional lateralization.
Sharon R Ladyman, Kirsten M Carter ... David R Grattan
Despite voluntary exercise being rewarding to mice, pregnancy hormones act in the maternal brain to markedly reduce the time females choose to engage in this activity.
Brandon G Rasman, Patrick A Forbes ... Jean-Sébastien Blouin
The nervous system can learn to control standing balance with added sensorimotor delays by causally linking delayed whole-body sensory feedback, initially deemed as unexpected, to self-generated balance motor commands.
Electrophysiological and structural characterizations reveal that a previously proposed ion channel responsible for sensing mechanical pain is insensitive to poking or stretching stimuli for conducting ions and may serve as a coenzyme A-binding protein instead.
The 3D structures of a membrane protein called TMEM120A suggest that it may act as an enzyme in fat metabolism rather than as an ion channel that senses mechanical pain.
Exposing subjects to the magnetic field of an MRI scanner stimulates the vestibular organ and thereby induces a horizontal bias of spatial orienting and exploration similar to that seen in stroke patients with spatial neglect.
