Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
Patricia M Horvath, Michelle K Piazza ... Ege T Kavalali
GABAergic postsynaptic responses mediated by spontaneous and evoked neurotransmitter release are partially segregated, suggesting they may serve distinct roles in neuronal signaling.
Keiko Weir, Christophe Dupre ... Nicholas W Bellono
Cnidarian stinging cells use a specialized voltage-gated calcium channel to integrate distinct sensory signals and selectively trigger a predatory response.
Top-down mediated decreases of beta activity in auditory cortex prior to a predictable distractor in an auditory working memory task is associated with increased representation of to-be-memorized information.
Alexander Shakeel Bates, James D Manton ... Gregory SXE Jefferis
Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
Acting in neuronal stem cells, temporal transcription factors, as a class of molecules, are uniquely potent determinants of circuit membership that establish expected patterns of wiring in the motor system.
Madhurima Dhara, Maria Mantero Martinez ... Dieter Bruns
Naturally-occurring v-SNARE TMD variants differentially regulate fusion pore dynamics and cooperate with phospholipids in supporting membrane curvature at the fusion pore neck.
A first principles, neuro-computational framework proposes a path for the experimental dissection of neural circuit mechanisms of competitive selection across brain areas and animal species.
Neuromodulation of the expression of Hebbian plasticity enables rapid cortical sensory-induced remodeling in post-critical period adults, and can rescue deficits induced by prolonged sensory deprivation.
