Browse our latest Neuroscience articles

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    1. Neuroscience

    Small molecule cognitive enhancer reverses age-related memory decline in mice

    Karen Krukowski, Amber Nolan ... Susanna Rosi
    Inhibition of the integrated stress response restores neuronal and immune dysfunction and alleviates memory deficits in aged mice.
    1. Neuroscience

    TrpML-mediated astrocyte microdomain Ca2+ transients regulate astrocyte–tracheal interactions

    Zhiguo Ma, Marc R Freeman
    Astrocyte microdomain calcium transients are mediated by TrpML, stimulated by ROS and tyramine, and mediate astrocyte–tracheal interactions in CNS gas exchange.
    1. Genetics and Genomics
    2. Neuroscience

    Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

    Yubo Cheng, Luke Saville ... Athanasios Zovoilis
    SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.
    1. Neuroscience

    The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines

    Kenrick Yap, Alexander Drakew ... Thomas Deller
    Long-term imaging of dentate granule cells reveals that the presence of synaptopodin within large spines, rather than their size, conveys long-term stability to large spines.
    1. Neuroscience

    Forced choices reveal a trade-off between cognitive effort and physical pain

    Todd A Vogel, Zachary M Savelson ... Mathieu Roy
    Cognitive effort is aversive and people will accept physical pain to avoid it, but this avoidance does not appear to share the same fundamental characteristics of pain avoidance.
    1. Computational and Systems Biology
    2. Neuroscience

    On the objectivity, reliability, and validity of deep learning enabled bioimage analyses

    Dennis Segebarth, Matthias Griebel ... Robert Blum
    A comparison of different bioimage analysis pipelines reveals how deep learning can be used for automatized and reliable analysis of fluorescent features in biological datasets.
    1. Computational and Systems Biology
    2. Neuroscience

    Deep Learning: Tackling the challenges of bioimage analysis

    Daniël M Pelt
    Using multiple human annotators and ensembles of trained networks can improve the performance of deep-learning methods in research.
    Version of Record
    Insight
    1. Neuroscience

    A selective effect of dopamine on information-seeking

    Valentina Vellani, Lianne P de Vries ... Tali Sharot
    L-DOPA administration increases information-seeking about potential losses without impacting information-seeking about potential gains, and as a result, it reduces the effect of valence on information-seeking.
    1. Neuroscience

    Curvature domains in V4 of macaque monkey

    Jia Ming Hu, Xue Mei Song ... Anna Wang Roe
    There is a systematic functional organization for curvature representation in area V4 where specific curvatures are encoded by unique values (modules) from the set of systematically represented values.
    1. Neuroscience

    Curvature-processing domains in primate V4

    Rendong Tang, Qianling Song ... Haidong D Lu
    Curvature-preferring neurons in monkey V4 cluster into 0.5-mm patches, which highlights the importance of curvature detection in visual object recognition and the key functional role of V4 in this process.