Browse our latest Neuroscience articles

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    1. Neuroscience

    Gradients in the biophysical properties of neonatal auditory neurons align with synaptic contact position and the intensity coding map of inner hair cells

    Alexander L Markowitz, Radha Kalluri
    The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
    1. Neuroscience

    Aberrant sorting of hippocampal complex pyramidal cells in type I lissencephaly alters topological innervation

    James A D'Amour, Tyler Ekins ... Chris J McBain
    The loss of lamination in mammalian brain structures under cellular heterotopia carries with it non-uniform ramifications for the various components of the canonical CA1 microcircuitry.
    1. Neuroscience

    Long-term implicit memory for sequential auditory patterns in humans

    Roberta Bianco, Peter MC Harrison ... Maria Chait
    Human listeners rapidly form robust, long lasting (up to 7 weeks) memories of rarely encountered, featureless sound sequences presented among many similar stimuli.
    1. Neuroscience

    Flexible motor sequence generation during stereotyped escape responses

    Yuan Wang, Xiaoqian Zhang ... Quan Wen
    Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
    1. Neuroscience

    Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

    Siqiang Ren, Wen Yao ... Luciano D'Adamio
    Analysis of rats carrying the microglia gene and Alzheimer risk factor Trem2R47H variant shows increased glutamatergic transmission via supraphysiological TNF-α brain concentrations, linking a microglia pathogenic variant to neuronal dysfunction.
    1. Neuroscience

    Apical length governs computational diversity of layer 5 pyramidal neurons

    Alessandro R Galloni, Aeron Laffere, Ede Rancz
    Layer 5 pyramidal neurons vary substantially in dendritic excitability between primary and secondary visual cortex, likely due to a counterintuitive amplifying effect of long apical dendrites.
    1. Neuroscience
    2. Physics of Living Systems

    Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback

    Joanne C Gordon, Natalie C Holt ... Monica A Daley
    Running guinea fowl maintain stable running after loss of the stretch reflex in a major ankle extensor muscle, by increasing feedforward muscle activation to maintain ankle stiffness and work output.
    1. Neuroscience

    Vestigial auriculomotor activity indicates the direction of auditory attention in humans

    Daniel J Strauss, Farah I Corona-Strauss ... Steven A Hackley
    Recordings of ear muscles in humans show that ears attempt to pivot in the direction that requires attention.
    1. Neuroscience

    Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages

    Timothy H Murphy, Nicholas J Michelson ... Jeff M LeDue
    A new methodology and protocol use automated brain imaging and task training technology to probe links between behavior and mouse cortical circuits.
    1. Neuroscience

    Temperature compensation in a small rhythmic circuit

    Leandro M Alonso, Eve Marder
    Computational models demonstrate that circuit resilience to temperature perturbations are associated with smooth transitions between cellular mechanisms as the contributions of different currents are altered while activity is maintained.