Michael Berger, Naubahar Shahryar Agha, Alexander Gail
The novel Reach Cage allows neurophysiology studies of structured behavior with unrestrained Rhesus macaques showing that the frontoparietal reach network is selective for reach goals outside the immediately reachable space.
Silvia JH Park, Evan E Lieberman ... Joshua H Singer
Anatomical and physiological analyses identified an inhibitory interneuron that is an integral part of the rod bipolar cell pathway, the circuit for night vision, of the mammalian retina.
Sheila Hoffmann-Conaway, Marisa M Brockmann ... Carolina Montenegro-Venegas
The presynaptic scaffolding protein Bassoon is involved in regulating neurotransmitter release by controlling synaptic vesicle pool size and vesicular protein turnover through increased ubiquitination and Parkin-dependent autophagy.
Beatriz Alvarez-Castelao, Susanne tom Dieck ... Erin M Schuman
In neurons, inhibition of the proteasome results in feedback inhibition of protein synthesis, mediated by heme-regulated kinase 1, which is optimized to act as both a sensor and an effector.
Zhuo Guan, Monica C Quiñones-Frías ... J Troy Littleton
Drosophila synaptotagmin 7 functions to restrict SV availability and release, but does not act as the Ca2+ sensor mediating the asynchronous release and facilitation remaining in synaptotagmin 1 mutants.
Networks simulations and in vivo imaging suggest a stable backbone of stimulus representation formed by neurons with low population coupling, alongside a flexible substrate of neurons with high population coupling.
During parallel fibre activity in vivo, postsynaptic mGluR1 receptors in molecular layer interneurons of the cerebellar cortex are engaged in a frequency-dependent manner and in concert with inotropic glutamate receptors.
Gilles Vannuscorps, Michael Andres, Alfonso Caramazza
It is possible to account for efficient facial expression recognition without having to invoke a mechanism of motor simulation, even in very sensitive and challenging tasks.
Ponto-spinal CRH neurons in Barrington’s nucleus are a core component of an inferential circuit that regulates autonomous micturition and generates voids when the bladder is full.