Threonine promotes sleep via down-regulation of metabotropic GABA transmission in the ellipsoid body R2 neurons that generate homeostatic sleep drive in Drosophila.
Jesús Rodriguez Curt, Behzad Yaghmaeian Salmani, Stefan Thor
The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
Delay-period activity of anterior piriform cortex is important for working memory tasks requiring active maintenance and encodes the maintained information.
Andrea KH Stavoe, Pallavi P Gopal ... Erika LF Holzbaur
The dynamic phosphorylation of autophagy component WIPI2B is critical to maintain autophagosome biogenesis in neurons, and ectopic expression of WIPI2B can restore rates of autophagosome biogenesis in aged neurons.
Vasoactive intestinal peptide-expressing GABAergic interneurons in cerebral cortex express the sodium channel subunit Nav1.1, and a defined subset of VIP interneurons are dysfunctional in a mouse model of Dravet syndrome.
A hub in the rostral anterior cingulate cortex receives unusually high and functionally diverse inputs, providing a biological interface between motivation, incentive based learning, and decision making.
Calcium imaging is used to construct a model of Caenorhabditis elegans nervous system dynamics capable of predicting future behavioral switches on a trial by trial basis and across individual animals.