Browse our latest Neuroscience articles

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    1. Genetics and Genomics
    2. Neuroscience

    Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive

    Yoonhee Ki, Chunghun Lim
    Threonine promotes sleep via down-regulation of metabotropic GABA transmission in the ellipsoid body R2 neurons that generate homeostatic sleep drive in Drosophila.
    1. Neuroscience

    Neuronal integration in the adult mouse olfactory bulb is a non-selective addition process

    Jean-Claude Platel, Alexandra Angelova ... Harold Cremer
    Adult neurogenesis in the olfactory bulb is not a turnover system but represents a lifelong neuronal addition mechanism.
    1. Developmental Biology
    2. Neuroscience

    Anterior CNS expansion driven by brain transcription factors

    Jesús Rodriguez Curt, Behzad Yaghmaeian Salmani, Stefan Thor
    The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
    1. Neuroscience

    Active information maintenance in working memory by a sensory cortex

    Xiaoxing Zhang, Wenjun Yan ... Chengyu T Li
    Delay-period activity of anterior piriform cortex is important for working memory tasks requiring active maintenance and encodes the maintained information.
    1. Cell Biology
    2. Neuroscience

    Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

    Andrea KH Stavoe, Pallavi P Gopal ... Erika LF Holzbaur
    The dynamic phosphorylation of autophagy component WIPI2B is critical to maintain autophagosome biogenesis in neurons, and ectopic expression of WIPI2B can restore rates of autophagosome biogenesis in aged neurons.
    1. Neuroscience

    Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

    Kevin M Goff, Ethan M Goldberg
    Vasoactive intestinal peptide-expressing GABAergic interneurons in cerebral cortex express the sodium channel subunit Nav1.1, and a defined subset of VIP interneurons are dysfunctional in a mouse model of Dravet syndrome.
    1. Neuroscience

    Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization

    Steven A Hill, Andrew S Blaeser ... A Denise R Garcia
    Astrocytes modulate synaptic remodeling of developing circuits in a cell type-specific manner, with long lasting deficits in synaptic plasticity.
    1. Neuroscience

    Impact of precisely-timed inhibition of gustatory cortex on taste behavior depends on single-trial ensemble dynamics

    Narendra Mukherjee, Joseph Wachutka, Donald B Katz
    Primary taste cortex does far more than code tastes by turning taste codes into motor commands via population dynamics.
    1. Neuroscience

    A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control

    Wei Tang, Saad Jbabdi ... Suzanne N Haber
    A hub in the rostral anterior cingulate cortex receives unusually high and functionally diverse inputs, providing a biological interface between motivation, incentive based learning, and decision making.
    1. Computational and Systems Biology
    2. Neuroscience

    A quantitative model of conserved macroscopic dynamics predicts future motor commands

    Connor Brennan, Alexander Proekt
    Calcium imaging is used to construct a model of Caenorhabditis elegans nervous system dynamics capable of predicting future behavioral switches on a trial by trial basis and across individual animals.