Research Communication

A Research Communication is an article that has been through an editorial process in which the authors decide how to respond to the issues raised during peer review.

Latest articles

    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

    Mashaal Sohail et al.
    Polygenic selection signals in humans estimated from previously existing GWAS should be viewed with caution due to concerns about residual population stratification.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Reduced signal for polygenic adaptation of height in UK Biobank

    Jeremy J Berg et al.
    Many prior signals of polygenic adaptation on human height do not replicate in the UK Biobank.
    1. Developmental Biology
    2. Evolutionary Biology

    The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning

    Suparna Ray et al.
    mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.
    1. Cell Biology

    Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

    Peipei Zhang et al.
    OptoGranules reveal the function of G3BP1 as a stress granule scaffold and demonstrate that protracted stress granule assembly is sufficient to drive neurodegeneration and the evolution of ALS-FTD pathology.
    1. Microbiology and Infectious Disease

    Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis

    Eva S Istvan et al.
    The malaria parasite Niemann-Pick Type C1-related protein is an important new antimalarial target.
    1. Genetics and Genomics

    Environmentally-induced epigenetic conversion of a piRNA cluster

    Karine Casier et al.
    Activation of a piRNA cluster is achieved by high temperature and without maternal inheritance of homologous piRNAs highlighting how variations of species natural habitat can become heritable and shape epigenome.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes

    Itamar Lev et al.
    In Caenorhabditis elegans histone methylation (H3K9me3) controls the synthesis of heritable small RNAs in a gene-specific manner and thus enables 'flagging' of newly-acquired genes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Regulating G protein-coupled receptors by topological inversion

    Bray Denard et al.
    Multiple biochemical assays show that the topology of CCR5 and possibly other GPCRs may be inverted by ceramide or other sphingolipids through the process of regulated alternative translocation.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Genetic and environmental perturbations lead to regulatory decoherence

    Amanda Lea et al.
    Infection and metabolic syndrome lead to a loss of molecular regulation, and changes in molecular correlations are under genetic control as revealed by the presence of correlation quantitative trait loci.
    1. Computational and Systems Biology
    2. Developmental Biology

    Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

    Idse Heemskerk et al.
    Live cell imaging demonstrates that the dynamics of ligand presentation influence signaling through two closely related morphogen signaling pathways in dramatically different ways.