Browse our latest Neuroscience articles

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    1. Neuroscience

    Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS

    Ernesto Manzo, Ileana Lorenzini ... Daniela C Zarnescu
    Degenerating motor neurons compensate for energetic deficits by upregulating glycolysis in flies and humans, with increased glucose availability improving locomotor function and lifespan in flies.
    1. Neuroscience

    Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling

    Thomas D James, Danielle J Zwiefelhofer, C Andrew Frank
    Synapses employ distinct acute and chronic signaling processes in order to maintain physiologically appropriate levels of function.
    1. Neuroscience

    Functional and anatomical specificity in a higher olfactory centre

    Shahar Frechter, Alexander Shakeel Bates ... Gregory Jefferis
    The Drosophila lateral horn, a higher olfactory brain area, contains >165 genetically defined cell types with stereotyped odour responses across animals and improved odor categorisation compared with their inputs.
    1. Neuroscience

    Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval in rats

    Briac Halbout, Andrew T Marshall ... Sean B Ostlund
    Inhibiting ventral tegmental dopamine neurons, or their inputs to nucleus accumbens, disrupts cue-motivated reward seeking in a manner that depends on the microstructure of behavior.
    1. Neuroscience

    Dissociating orexin-dependent and -independent functions of orexin neurons using novel Orexin-Flp knock-in mice

    Srikanta Chowdhury, Chi Jung Hung ... Akihiro Yamanaka
    Subtraction analysis using novel Orexin-Flp mice isolated physiological importance of orexin peptides.
    1. Neuroscience

    GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice

    Srikanta Chowdhury, Takanori Matsubara ... Akihiro Yamanaka
    Functional identification of GABAergic neurons in the ventral tegmental area as a important neuronal subpopulation regulating non-rapid eye movement (NREM) sleep in mice.
    1. Neuroscience

    Self-organized reactivation maintains and reinforces memories despite synaptic turnover

    Michael Jan Fauth, Mark CW van Rossum
    Despite ongoing rewiring and continuous turnover of synapses, a computational model shows that memories can maintain and even strengthen their connectivity by self-reactivating during periods without sensory input.
    1. Neuroscience

    Context-dependent signaling of coincident auditory and visual events in primary visual cortex

    Thomas Deneux, Evan R Harrell ... Brice Bathellier
    Abrupt sounds boost coincident visual cortex responses which could help localization of sudden audio-visual events.
    1. Neuroscience

    PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice

    Achira Roy, Rory M Murphy ... Kathleen J Millen
    Embryonic PI3K-Yap activity regulates apical adhesion and proliferation of neural progenitors lining the lateral ventricular surface, to maintain the smooth, non-folded mouse brain and to prevent developmental hydrocephalus.
    1. Neuroscience

    Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

    Mary L Phillips, Holly Anne Robinson, Lucas Pozzo-Miller
    Input from the ventral hippocampus to the medial prefrontal cortex regulates social memory in wild type mice and atypically-strengthened input causes social memory dysfunction in Rett syndrome mice.