After mating, female mice form a sensory memory of the stud male's pheromones that correlates with striking changes in responsiveness of the specific neural ensemble activated by her partner.
John P Grogan, Demitra Tsivos ... Elizabeth J Coulthard
Memory over 24 hours was impaired in Parkinson's patients off, rather than on, dopaminergic medication during reinforcement learning, whereas dopamine did not affect positive and negative reinforcement, in contrast to previous studies.
The subcortical visual pathway through the midbrain superior colliculus is responsible for visually evoked Pavlovian conditioning and dopamine neuron responses with predicted value in monkeys, which remained after lesioning V1.
Oligomeric Amyloid-β and Tau, two proteins involved in Alzheimer's disease pathogenesis, require Amyloid Precursor Protein to enter neurons and exert their detrimental effect on synaptic plasticity and memory.
Philipp Janz, Niels Schwaderlapp ... Carola A Haas
Non-invasive imaging of hippocampal neurodegeneration and structural reorganization during epileptogenesis allows the prediction of disease severity in mesial temporal lobe epilepsy, which may facilitate the early pharmacological intervention before seizure onset.
Comparison of the intracellular activity of hippocampal neurons in novel and familiar environments reveals experience-dependent changes in inputs underlying the formation of stable representations of space.
Sudden stopping of rhythmic movement is associated with a pronounced increase of 60-90 Hz gamma oscillations in the subthalamic nucleus, which have formerly been regarded as favouring movement.
Kathryn H Fife, Navarre A Gutierrez-Reed ... Thomas S Hnasko
Activation of the subthalamic nucleus (STN) pauses or disrupts behavior, while STN inhibition reduces the disruptive effects of surprise, indicating that STN activation is both sufficient and necessary for behavioral inhibition.
