Vijayendran Chandran, Kun Gao ... Daniel H Geschwind
Restoration of endogenous frataxin levels reverses neurologic and cardiac phenotypes associated with Friedreich's ataxia in adult mice even after significant motor dysfunction.
Ronen Reshef, Elena Kudryavitskaya ... Raz Yirmiya
During adult neurogenesis in the olfactory bulb, microglia regulate the elimination (pruning), formation, and maintenance of synapses on newborn neurons, contributing to the functional integrity of the olfactory bulb circuitry.
Single-unit activity consistent with a selective causal role in reactive stopping or switching behaviors is found only in the most ventromedial subregion of the subthalamic nucleus.
Clarinet, a novel C. elegans active zone protein with homology to vertebrate Piccolo and Rim, uses its different isoforms for diverse functions, including synaptic vesicle clustering, vesicle release and synaptogenesis.
A cellular-level in vivo investigative method that provides unprecedented insights into the dynamics of neuronal activities evoked by transcranial magnetic stimulation.
Three distinct AKT isoforms are found in the brain and show dissimilar patterns of expression, differential roles in the expression of synaptic plasticity, and different roles in neuronal signaling.
Using targeted functional manipulations of neural activity to map neuromodulatory connections can deliver considerable insight into the functional architecture of a behaviorally important network even in the absence of information about its synaptic connectivity.
