Browse our latest Neuroscience articles

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    1. Neuroscience

    Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression

    Edward Pym, Nikhil Sasidharan ... Joshua M Kaplan
    Changes in Shank gene dosage alter voltage-activated calcium current and calcium-activated gene expression in a manner that parallels the effects of human Shank copy number variation on psychiatric disease risk.
    1. Neuroscience

    Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action

    Jennifer C Swart, Monja I Froböse ... Hanneke EM den Ouden
    Motivational coupling of action to reward and inhibition to punishment is subserved by dissociable learning and choice processes, and is modulated by dopamine/noradrenaline transporter blockade.
    1. Developmental Biology
    2. Neuroscience

    Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

    Melinda S Modrell, Mike Lyne ... Clare VH Baker
    An unbiased transcriptomic approach reveals that developing paddlefish electrosensory organs express genes essential for mechanosensory hair cell development and synaptic transmission, and identifies candidates for mediating electroreceptor development and function.
    1. Neuroscience

    Synaptic input sequence discrimination on behavioral timescales mediated by reaction-diffusion chemistry in dendrites

    Upinder Singh Bhalla
    The powerful computational operation of sequence recognition on behavioral timescales of approximately 1 s may emerge from synaptic activity-triggered build-up of biochemical waves in short 20 micron zones on dendrites.
    1. Neuroscience

    Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning

    Isaac Cervantes-Sandoval, Anna Phan ... Ronald L Davis
    Structural and functional analysis of axonal-axonal reciprocal connections between dopamine neurons and Kenyon cells provides insight into the brain computations for normal associative olfactory learning.
    1. Neuroscience

    Noradrenaline blockade specifically enhances metacognitive performance

    Tobias U Hauser, Micah Allen ... Raymond J Dolan
    The neurotransmitter noradrenaline selectively modulates metacognition, the conscious insight into one's performance, but does not alter perceptual decision making, revealing that different neuromodulators affect different stages of a decision making process.
    1. Developmental Biology
    2. Neuroscience

    A novel perivascular cell population in the zebrafish brain

    Marina Venero Galanternik, Daniel Castranova ... Brant M Weinstein
    A new brain perivascular cell type in the zebrafish related to mammalian Fluorescent Granular Perithelial (FGP) cells emerges directly from endothelium during early development.
    1. Cell Biology
    2. Neuroscience

    Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses

    Laurent Guillaud, Dimitar Dimitrov, Tomoyuki Takahashi
    In central synapses, the mobility and supply of synaptic vesicles are determined by two independent biological factors: the morphological and structural organization of nerve terminals and the molecular signature of vesicles.
    1. Neuroscience

    Sequential sensory and decision processing in posterior parietal cortex

    Guilhem Ibos, David J Freedman
    Comparison of feature encoding and top-down cognitive signals gives insight into the role of parietal cortex in mediating decision making.
    1. Neuroscience

    Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe

    Virginia E Hawkins, Ana C Takakura ... Daniel K Mulkey
    CO2/H+-dependent purinergic signaling by astrocytes provides specialized control of vascular tone in a brainstem respiratory center in a manner that contributes to respiratory behavior.