Human neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.
Psilocin induces a durable neuroplastic state in human cortical neurons by enhancing BDNF signaling, neurite complexity, synaptogenesis, and synaptic network activity through 5-HT2A receptor-dependent mechanisms.
Rigorous analysis in two knockout mouse lines demonstrates that death receptor 6 is not required for axon degeneration or Schwann cell injury responses following peripheral nerve transection.
Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith
Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
