LRRK2 couples brain-derived neurotrophic factor (BDNF) signaling to synaptic actin remodeling, defining a novel mechanism of LRRK2 synaptic function and highlighting early, targetable pathways in Parkinson’s disease.
Estrogen receptor 1 (ESR1)-positive neurons in the pontine micturition center govern detrusor–sphincter coordination via three distinct spinal projections, representing a therapeutic target for detrusor–sphincter dyssynergia and associated voiding dysfunction.
Alessio Paolo Buccino, Arjun Sridhar ... Joshua H Siegle
Parallelized, cloud-compatible pipelines reduce spike sorting of large-scale neural recordings from weeks to hours, and enable systematic benchmarking of algorithms on hybrid data.
Age-specific templates improve the quality of functional alignment using hyperalignment algorithms, and the improvement is consistent across age groups, validation analyses, and datasets.
