Browse our latest Neuroscience articles

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    1. Neuroscience

    Quantification of the effect of hemodynamic occlusion in two-photon imaging of mouse cortex

    Baba Yogesh, Matthias Heindorf ... Georg B Keller
    Hemodynamic occlusion introduces a spatially heterogenous confound to activity measurements using two-photon and widefield imaging in mouse cortex, and needs to be taken into consideration when interpreting functional imaging data.
    1. Medicine
    2. Neuroscience

    Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

    Joanna Kosinska, Julian C Assmann ... Markus Schwaninger
    The therapeutic effect of dimethyl fumarate in experimental autoimmune encephalomyelitis depends on the diet of mice and is mediated by the G protein-coupled receptor HCAR2 in neutrophils.
    1. Neuroscience

    Integration of head and body orientations in the macaque superior temporal sulcus is stronger for upright bodies

    Yordanka Zafirova, Rufin Vogels
    Head and body orientation cues are integrated by macaque superior temporal sulcus neurons, with stronger integration for upright monkey images.
    1. Neuroscience

    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
    Targeting EMC10 restores neuronal function in 22q11.2DS patient-derived neurons and reverses cognitive deficits in adult mice, highlighting its potential as a therapeutic strategy for mitigating disease-related cognitive impairments.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

    Robert G Stewart, Matthew James Marquis ... Jon T Sack
    Drugs are identified that unmask molecular origins of certain neuronal potassium currents, enabling functional analysis of previously indistinguishable potassium channel subtypes.
    1. Developmental Biology
    2. Neuroscience

    Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline

    Kelly G Sullivan, Greg J Bashaw
    Commissureless works with the Nedd4 E3 ubiquitin ligase to transiently degrade the Robo1 receptor to allow commissural axons to cross the midline.
    Version of Record
    Research Article
    • Fundamental
    • Compelling
    • Convincing
    1. Neuroscience

    Network segregation is associated with processing speed in the cognitively healthy oldest-old

    Sara A Nolin, Mary E Faulkner ... Kristina M Visscher
    Greater differentiation of brain networks is a hallmark of good cognitive functioning among individuals who have avoided neurodegenerative disease and live longer than a typical human lifespan.
    1. Neuroscience

    Subcortical correlates of consciousness with human single neuron recordings

    Michael Pereira, Nathan Faivre ... Olaf Blanke
    Subcortical brain structures contain neurons encoding subjective reports of stimulus detection in human participants, suggesting a role for conscious perception.
    1. Neuroscience

    Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories

    Rebecca RG, Giorgio A Ascoli ... Holger Dannenberg
    The characteristic hexagonal firing pattern of grid cells emerges as the most parsimonious solution to a trajectory code by cell sequences.
    1. Cell Biology
    2. Neuroscience

    Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival

    Moloy T Goswami, Eric Weh ... Thomas J Wubben
    For the first time, mouse models reveal the metabolic dependency of photoreceptors on glutamine catabolism in vivo and further demonstrate the flexibility of photoreceptors to utilize fuel sources beyond glucose.