Super-resolution imaging reveals how the skeleton that supports the outer membrane of axons is assembled during development, and provides an explanation for why this structure preferentially forms in axons but rarely in dendrites.
Faced with multiple sources of sound, humans can better perceive all of a target sound's features when one of those features changes in time with a visual stimulus.
Diane M Bushman, Gwendolyn E Kaeser ... Jerold Chun
Somatically derived genomic mosaicism in the form of increased DNA content and APP copy number in single neurons plausibly has a function in sporadic Alzheimer’s disease and points to functions for single-neuron gene copy number changes.
The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.
The spatial regulation of gene expression within neurons occurs primarily at the level of local translation rather than by stimulus-induced RNA targeting from nucleus to synapse.
Neuronal networks balance flexibility with stability by allowing the firing rate of individual neurons within a network to vary over time, while ensuring that the average firing rate across the network remains constant.
Large-scale changes in the brain's functional circuitry can be brought about by simple changes in gene expression in neural stem cells during development.
Michael Schleyer, Daisuke Miura ... Bertram Gerber
The finding that fly maggots, equipped with only 10,000 neurons, process reinforcement not only by value but also by specific quality reveals a basic operating principle of brains and challenges current models of memory organization.
Neural representations are fast-evolving trajectories, and distinct components of these trajectories reappear during retrieval with distinct consequences for learning.
