The naturally occurring biologics, FLO and HC-HA/PTX3, derived from human birth tissues, may be developed as a much-needed non-opioid therapy for post-surgical pain treatment, leveraging robust neuronal mechanisms.
Kiss1ARH neurons transition from synchronous to burst firing under preovulatory levels of E2, causing a shift from peptidergic to glutamatergic transmission that drives the GnRH surge through enhanced glutamate neurotransmission.
Studies with mice and brain organoids models reveals that dysregulation of GTF2IRD1-TTR-ERK pathway significantly contributes to neuronal deficits of Williams syndrome.
Luis Sánchez-Guardado, Peyman Razavi ... Carlos Lois
Ablation of olfactory projection neurons in adult mice triggers sprouting of the apical dendrite of remaining neurons towards multiple nearby glomeruli and disrupts the odor map.
Developmental specialization of vomeronasal sensory neurons involves selective upregulation of endoplasmic reticulum genes in a subset of neurons along with a hypertrophic gyroid membrane architecture.
Jayanarayanan Sadanandan, Sithara Thomas ... Peeyush Kumar T
Histone deacetylase 2 (HDAC2) and polycomb repressive complex 2 (PRC2) control endothelial gene expression for BBB development and prevented Wnt/β-catenin target genes from being expressed in adult CNS ECs.
