LINE-1-encoded ORF1p is widely expressed in neurons, increases with age, and engages neuron-specific protein partners, revealing a dynamic role for retrotransposons in brain physiology and aging.
CryoCLEM-guided cryoET of Psd95-GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.
Recurrent neural network and its readout (cortex–striatum) can learn state representation and value using online random-weight feedback of temporal-difference reward-prediction-error (dopamine) through feedback alignment or biological non-negative-weight constraint-induced loose alignment.
To parse foreground and background sounds, the auditory cortex of humans and ferrets share a similar hierarchical organization, but the underlying computational mechanisms are fundamentally different.
