The opposing dopamine receptors Dop1R1 and Dop2R are both enriched around the pre- and postsynaptic sites of different types of neurons, including dopaminergic neurons, in the fly brain.
The inferior colliculus integrates auditory and cognitive functions, playing critical roles in sensory prediction, reward processing, and decision-making beyond its traditional role as a sensory relay.
Rituja S Bisen, Fathima Mukthar Iqbal ... Jan M Ache
An in vivo electrophysiology approach identifies an incretin-like effect in Drosophila insulin-producing cells, highlighting key circuit dynamics which govern glucose homeostasis via conserved mechanisms.
Hendrik Heinbockel, Gregor Leicht ... Lars Schwabe
Impairing effects of post-retrieval noradrenergic but not glucocorticoid activation on future recall are linked to hippocampal reactivation and category-level reinstatement in ventral temporal cortex during memory retrieval.
Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.
Ilya A Rybak, Natalia A Shevtsova ... Alain Frigon
Computational modeling based on experimental data reveals how spinal sensorimotor circuits control cycle and phase durations during treadmill locomotion after an incomplete spinal cord injury.
In feedforward networks with random connectivity, connection motifs underlying the detection of short clusters and activity sequences are likely to converge on a subset of postsynaptic neurons purely by chance.
