Downregulation of PTBP1 in neurons, but not astrocytes, alleviates motor symptoms in a Parkinson’s disease mouse model by inducing dopaminergic marker expression in striatal neurons and increasing striatal dopamine levels.
Distinct frequency-based interactions between cortical and subcortical regions highlight the cerebellum’s crucial role in speech production and perception.
A novel molecular mechanism linking a neurotrophin with a Toll-family and kinase-less Trk-like receptors provides a direct link from molecules to structural circuit plasticity and modification of behaviour.
A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
Josse Poppinga, Nolan J Barrett ... Jan RT van Weering
SNX4 influences synaptic vesicle recruitment at the active zone, linking endosomal sorting to docked vesicle density and modulating neurotransmission efficiency during sustained activity.
RNA-Seq analysis and molecular biological approaches reveal a novel mechanism and provide a promising preventive and therapeutic molecular target for vulnerability to chronic pain-related memory impairment.
