A circuit within the nucleus accumbens that exists during a specific developmental window through early adolescence male rats may serve as a substrate that underlies heightened reward seeking in this population.
Locomotion triggers a binary state transition in cortical acetylcholine levels that increase top-down and bottom-up responses in layer 5 but not layer 2/3 neurons.
Adolescent brain development involves dopamine axon growth and a coincident change in UNC5c receptor expression, both of which are responsive, in unison, to an environmental signal.
Common cognitive maps across feature dimensions are spontaneously leveraged to facilitate storage of multiple sequences via compressed encoding and neural replay in human working memory.
Jaebin Kim, Edwin Bustamante ... Scott H Soderling
Presynaptic Rac1 inhibition in the hippocampus impairs spatial working memory, potentially by modulating the synaptic cytoskeleton and kinase-mediated phosphorylation of key synaptic vesicle proteins.
Sophie Peterson, Amanda Maheras ... Ronald Keiflin
Rodent model of context-dependent discrimination reveals sex-biased tradeoff between speed of acquisition and robustness of contextual control over cue-elicited reward seeking, linked to orbitofrontal cortex activation.
Abnormal activity in the cerebellar nuclei can be used to predict motor symptoms and induce them experimentally, pointing to potential therapeutic strategies.
