Neuroscience

Latest articles

1. 1. Neuroscience

   MeCP2 in cholinergic interneurons of nucleus accumbens regulates fear learning

   Ying Zhang et al.

   Robust fear learning deficits and decreased tonic activity of NAc cholinergic interneurons caused by depletion of MeCP2 could be attributed to an elevation in α2-containing GABA_A receptors.
2. 1. Neuroscience

   Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

   Matthew Grove et al.

   YAP and TAZ, potent concoproteins and therapeutic targets in cancer therapy, are essential for Schwann cells to support peripheral nerve regeneration.
3. 1. Neuroscience

   Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults

   Alexandra N Trelle et al.

   The strength of pattern completion during memory retrieval, indexed by hippocampal activity and cortical reinstatement, explains within- and across-individual variability in episodic memory in older adults.
4. 1. Neuroscience
   2. Structural Biology and Molecular Biophysics

   Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

   Siyuan Zhao et al.

   Disease-associated mutants of the TRPM3 ion channel are overactive, and they are inhibited by the antiepileptic medication primidone, offering a potential therapeutic intervention to treat this channelopathy.
5. 1. Neuroscience

   Principles of operation of a cerebellar learning circuit

   David J Herzfeld et al.

   Quantitative analysis of behavior coupled with computational modeling reveal the set of circuit-level principles that underlie cerebellar-dependent motor learning in smooth pursuit eye movements of monkeys across timescales.
6. 1. Neuroscience

   Effects of fluorescent glutamate indicators on neurotransmitter diffusion and uptake

   Moritz Armbruster et al.

   Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.
7. 1. Evolutionary Biology
   2. Neuroscience

   True S-cones are concentrated in the ventral mouse retina and wired for color detection in the upper visual field

   Francisco M Nadal-Nicolás et al.
8. 1. Cell Biology
   2. Neuroscience

   Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

   Kirby M Donnelly et al.
9. 1. Neuroscience

   Apical length governs computational diversity of layer 5 pyramidal neurons

   Alessandro R Galloni et al.
10. 1. Neuroscience

    TUBB4A mutations result in both glial and neuronal degeneration in an H-ABC leukodystrophy mouse model

    Sunetra Sase et al.

    H-ABC leukodystrophy results in neurologic decline, hypomyelination and atrophy of the striatum and cerebellum and Tubb4a^D249N/D249Nmouse model recapitulates features of H-ABC disease, providing an important tool for therapeutic development.