Intracellular protein gradients, which are formed by the combined action of cytoplasmic diffusion and cortical transport toward the cell pole, are solely determined by cell shape.
When crowded bacterial colonies invade a closed area, flow-induced alignment creates strong radial orientation and leads to the formation of aster defects.
Quantitative proof that persistent cell migration in the timescale of hours relies on a feedback between polarized trafficking and protrusive activity stabilizing cell front.
Electrical and biomechanical stimuli directly bias cortical signal transduction and cytoskeletal waves, and the direct bias induced by an electric field develops slowly compared to the rapid surface-receptor-mediated response to chemotactic gradients.
Mitochondrial metabolic fluxes display a subcellular spatial gradient within a single mouse oocyte, and the fluxes are not controlled by nutrient supply or energy demand of the cell, but by the intrinsic rates of mitochondrial respiration.
Integrated live cell imaging and image analyses in the framework of transition path theories identify epithelial-to-mesenchymal transition proceeds through parallel paths.
The integration of biplanar X-ray videos with 3D X-ray particle tracking revealed that fish use a combination of intraoral 'central jet' waterflow pattern and inertia to guide food toward the digestive tract during suction feeding.
