Browse our latest Physics of Living Systems articles

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    1. Neuroscience
    2. Physics of Living Systems

    A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy

    Matthew W Rozak, James R Mester ... Bojana Stefanovic
    A novel pipeline for analyzing longitudinal two-photon microscopy data of cerebrovasculature in mice interrogates the vasculature network before and after optogenetic stimulation, revealing new insights into their coordination.
    1. Physics of Living Systems

    The cytoplasm of living cells can sustain transient and steady intracellular pressure gradients

    Majid Malboubi, Mohammad Hadi Esteki ... Guillaume Charras
    Stable pressure gradients can arise in cells from the combination of actomyosin-generated cortical tension, cytoplasmic poroelasticity, and water flows across the membrane.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A Coma Pattern-Based Autofocusing Method Resolves Bacterial Cold Shock Response at Single-Cell Level

    Sihong Li, Zhixin Ma ... Shuqiang Huang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Should I stay or should I go? Spatiotemporal dynamics of bacterial biofilms in confined flows

    Massinissa Benbelkacem, Gabriel Ramos ... Yohan Davit
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience
    2. Physics of Living Systems

    “What” × “When” working memory representations using Laplace Neural Manifolds

    Aakash Sarkar, Shangfu Zuo ... Marc W Howard
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology
    2. Physics of Living Systems

    Convergent Cellular Adaptation to Freeze-Thaw Stress via a Quiescence-like State in Yeast

    Charuhansini Tvishamayi, Farhan Ali ... Shashi Thutupalli
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Physics of Living Systems

    Feeding rates in sessile versus motile ciliates are hydrodynamically equivalent

    Jingyi Liu, Yi Man ... Eva Kanso
    Fluid flow analysis reveals that both swimming and sessile ciliates achieve competitive nutrient uptake, resolving the long-standing debate over the hydrodynamic advantage of either strategy.
    1. Cancer Biology
    2. Physics of Living Systems

    Robust assessment of asymmetric division in colon cancer cells

    Domenico Caudo, Chiara Giannattasio ... Mattia Miotto
    Combining statistical modeling with flow cytometry enables reliable, high-throughput quantification of division asymmetry in live cells, revealing how partitioning noise may shape tumor cell heterogeneity.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Cluster size determines internal structure of transcription factories in human cells

    Massimiliano Semeraro, Giuseppe Negro ... Davide Marenduzzo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Physics of Living Systems

    Linking complex microbial interactions and dysbiosis through a disordered Lotka–Volterra model

    Jacopo Pasqualini, Amos Maritan ... Samir Suweis
    Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.