Browse our latest Physics of Living Systems articles

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    1. Physics of Living Systems

    Mechanical basis and topological routes to cell elimination

    Siavash Monfared, Guruswami Ravichandran ... Amin Doostmohammadi
    Using self-organization, cells can collectively leverage defects in nematic and hexatic orders to localize mechanical stresses and remove an unwanted cell with their preferred path to achieve this explored here by independently tuning cell–cell and cell–substrate adhesion strengths.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    An optimal regulation of fluxes dictates microbial growth in and out of steady state

    Griffin Chure, Jonas Cremer
    Microbial cells optimally structure their proteomes in order to mutually maximize metabolism and translation, as established by an extensive comparison between data and a low-dimensional model of cellular physiology.
    1. Neuroscience
    2. Physics of Living Systems

    Exploring the role of the outer subventricular zone during cortical folding through a physics-based model

    Mohammad Saeed Zarzor, Ingmar Blumcke, Silvia Budday
    Continuum mechanics-based computational modeling provides insights into the interplay between cell proliferation in different zones of the developing human brain and the evolving cortical folding patterns.
    1. Genetics and Genomics
    2. Physics of Living Systems

    Coarsening dynamics can explain meiotic crossover patterning in both the presence and absence of the synaptonemal complex

    John A Fozard, Chris Morgan, Martin Howard
    Mathematical modelling, together with super-resolution imaging in Arabidopsis, demonstrates that a recently proposed coarsening model for meiotic crossover interference can explain the dynamic patterning of crossovers in many contexts, including in zyp1 and pch2 chromosome structure mutants.
    1. Physics of Living Systems

    In-line swimming dynamics revealed by fish interacting with a robotic mechanism

    Robin Thandiackal, George Lauder
    Fish in the thrust wake of a flapping foil reduce tail-beat frequencies, synchronize with oncoming vortices, and swim energetically more efficiently.
    1. Physics of Living Systems

    Animal Locomotion: The benefits of swimming together

    Iain D Couzin, Liang Li
    When a fish beats its tail, it produces vortices in the water that other fish could take advantage of to save energy while swimming.
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    1. Physics of Living Systems
    2. Neuroscience

    How human runners regulate footsteps on uneven terrain

    Nihav Dhawale, Madhusudhan Venkadesan
    When running on uneven terrain, humans mostly rely on the body's mechanical response for stability instead of planning their footsteps to seek out level ground.
    1. Developmental Biology
    2. Physics of Living Systems

    Controlling periodic long-range signalling to drive a morphogenetic transition

    Hugh Z Ford, Angelika Manhart, Jonathan R Chubb
    Cells control signal circulation to set the frequency of information transmitted over tissue scales.
    1. Physics of Living Systems

    Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome

    Sae-Il Murtada, Nicole Mikush ... Jay D Humphrey
    Daily administration of the farnesyltransferase inhibitor lonafarnib decreases central artery stiffness, increases distal artery vasoactivity, and improves left ventricular function consistent with increased survival in a mouse model of Hutchinson-Gilford progeria syndrome.
    1. Neuroscience
    2. Physics of Living Systems

    Granger causality analysis for calcium transients in neuronal networks, challenges and improvements

    Xiaowen Chen, Faustine Ginoux ... Claire Wyart
    A practical toolbox for application of Granger causality inference to calcium imaging data identifies strong driver neurons in the locus of the mesencephalic locomoter region in larval zebrafish.