Browse our latest Physics of Living Systems articles

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    1. Physics of Living Systems

    Speed variations of bacterial replisomes

    Deepak Bhat, Samuel Hauf ... Simone Pigolotti
    The speed of replisomes in Escherichia coli depends on temperature and varies along the genome in a wave-like manner, with implications for bacterial physiology.
    1. Physics of Living Systems

    Learning to predict target location with turbulent odor plumes

    Nicola Rigolli, Nicodemo Magnoli ... Agnese Seminara
    Intensity of an odor and timing of its detection are complementary attributes of turbulent plumes and enable robust prediction of the location of a distant target.
    1. Cell Biology
    2. Physics of Living Systems

    Three-dimensional structure of kinetochore-fibers in human mitotic spindles

    Robert Kiewisz, Gunar Fabig ... Thomas Müller-Reichert
    Comprehensive 3D electron tomography reconstructions of metaphase spindles in human tissue culture cells reveal that kinetochore-fibers broaden as they extend polewards, forming semi-direct connections to the pole, where they preferentially interact with the spindle network.
    1. Physics of Living Systems

    Interplay of surface interaction and magnetic torque in single-cell motion of magnetotactic bacteria in microfluidic confinement

    Agnese Codutti, Mohammad A Charsooghi ... Stefan Klumpp
    Confined magnetotactic bacteria exhibit circling and U-turn trajectories explained by a competition of alignment with a magnetic field and alignment along the confining walls as well as considerable cell-to-cell heterogeneity.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Lactoferricins impair the cytosolic membrane of Escherichia coli within a few seconds and accumulate inside the cell

    Enrico F Semeraro, Lisa Marx ... Georg Pabst
    The damage of the bacterial cell envelope is found to be only a secondary effect of the antimicrobial activity of lactoferricin derivatives.
    1. Neuroscience
    2. Physics of Living Systems

    Label-free three-photon imaging of intact human cerebral organoids for tracking early events in brain development and deficits in Rett syndrome

    Murat Yildirim, Chloe Delepine ... Mriganka Sur
    Label-free three-photon imaging of whole, uncleared intact organoids generated from Rett syndrome patients show shorter migration distances and slower migration speeds of mutant radially migrating neurons with more tortuous trajectories.
    1. Cell Biology
    2. Physics of Living Systems

    Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5 dynamics depending on its dimerization status

    Fanny Momboisse, Giacomo Nardi ... Anne Brelot
    Combining particle tracking in living cells with statistical analysis demonstrates how the oligomeric organization of cell surface receptor influences their function, a necessary step in the development of drugs targeting specific receptor conformation.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A biophysical threshold for biofilm formation

    Jenna A Moore-Ott, Selena Chiu ... Sujit S Datta
    A biophysical model of the process by which bacteria transition from the motile planktonic state to the immobilized biofilm state yields testable predictions in terms of two dimensionless parameters, one describing nutrient availability and the other describing cellular dispersal.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Bacteria: To biofilm or not to biofilm

    Shravan Pradeep, Paulo E Arratia
    A new model helps to predict under which conditions a species of bacteria will switch to a static lifestyle.
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    1. Physics of Living Systems

    Hydrodynamic model of fish orientation in a channel flow

    Maurizio Porfiri, Peng Zhang, Sean D Peterson
    A hydrodynamic model of fish swimming in a channel predicts a critical flow speed for fish to successfully swim against a flow, unveiling a passive mechanism for rheotaxis to emerge without access to any sensory information.