Browse our latest Physics of Living Systems articles

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    1. Physics of Living Systems

    Dynamics of immune memory and learning in bacterial communities

    Madeleine Bonsma-Fisher, Sidhartha Goyal
    1. Physics of Living Systems

    Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer

    Yang Joon Kim, Kaitlin Rhee ... Hernan G Garcia
    The combination of theoretical modeling and quantitative live imaging revealed that the repressor proteins work cooperatively or anti-cooperatively depending on enhancer architecture.
    1. Developmental Biology
    2. Physics of Living Systems

    On the origin of universal cell shape variability in confluent epithelial monolayers

    Souvik Sadhukhan, Saroj Kumar Nandi
    The nearly universal nature of scaled cell shape variability in an epithelial monolayer is unavoidable, irrespective of health or disease, as it comes from a mathematical property.
    1. Cell Biology
    2. Physics of Living Systems

    Fixation can change the appearance of phase separation in living cells

    Shawn Irgen-Gioro, Shawn Yoshida ... Shasha Chong
    Different fixation protocols can both enhance and diminish the appearance of liquid–liquid phase separation (LLPS) droplets presenting a caveat in using fixed-cell imaging to diagnose LLPS.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

    Nil Z Gurel, Koustubh B Sudarshan ... Olujimi A Ajijola
    Networked cardiac control, revealed through analysis of extended baseline-state multi-channel recordings, differentiates heart failure and normal regimes highlighting the promise of peripheral neurally based clinical interventions.
    1. Physics of Living Systems

    How enzymatic activity is involved in chromatin organization

    Rakesh Das, Takahiro Sakaue ... Tetsuya Hiraiwa
    Computer simulations considering actions of the intranuclear enzyme, Topoisomerase-II, in a mechanistic scheme elucidated a capability of enzymes to contribute to controlling chromatin spatial organizations and discovered new characteristic features in eu- and heterochromatin organization caused by the enzymatic activity.
    1. Cell Biology
    2. Physics of Living Systems

    Dependence of diffusion in Escherichia coli cytoplasm on protein size, environmental conditions, and cell growth

    Nicola Bellotto, Jaime Agudo-Canalejo ... Victor Sourjik
    Diffusion of differently sized proteins in bacterial cytoplasm is nearly Brownian and consistent with the Stokes-Einstein relation, once protein shape and cell geometry are taken into account, and effects of various perturbation can be described as changes in cytoplasmic viscosity.
    1. Physics of Living Systems
    2. Plant Biology

    Environmental morphing enables informed dispersal of the dandelion diaspore

    Madeleine Seale, Oleksandr Zhdanov ... Naomi Nakayama
    The dandelion diaspore changes its shape depending on the moisture levels in the air, and this morphing enhances the dispersal potential of the seeds regardless of the weather conditions.
    1. Cell Biology
    2. Physics of Living Systems

    Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19

    Steffen M Recktenwald, Greta Simionato ... Stephan Quint
    For severe COVID-19 patients' red blood cells, healthy donor plasma reduces pathological red blood cell shape alterations and improves microcapillary flow in vitro through an interaction between red blood cells and plasma.
    1. Physics of Living Systems

    The importance of intermediate filaments in the shape maintenance of myoblast model tissues

    Irène Nagle, Florence Delort ... Myriam Reffay
    Specific to muscles and essential for their development, desmin is revealed to be fundamental to the mechanics and shape maintenance of model muscle tissue even in early differentiating and unorganized systems through an integrated magnetic tensiometer approach.