Browse our latest Physics of Living Systems articles

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    1. Physics of Living Systems

    Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori

    Jyot D Antani et al.
    Asymmetric forward and backward swimming speeds reveal that the rotational bias, and not reversal frequencies, is an appropriate measure of chemotaxis signaling in Helicobacter pylori..
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Proofreading through spatial gradients

    Vahe Galstyan et al.
    Theoretical study shows how enzymes can achieve substrate proofreading by taking advantage of existing molecular gradients in the cell while not being endowed with structural features typically required for proofreading.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis

    Lior Strinkovsky et al.
    Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    The interplay between asymmetric and symmetric DNA loop extrusion

    Edward J Banigan, Leonid A Mirny
    Models of chromosome compaction by condensins demonstrate that two-sided loop extrusion and long residence times are required for high compaction, suggesting a tight coupling between these two properties in vivo.
    1. Cell Biology
    2. Physics of Living Systems

    Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

    Yong Li et al.
    Elastic forces generated by the giant protein titin define both passive and active tension of skeletal muscle fibers and protect the sarcomeric myosin filaments from severe disruption during contraction.
    1. Physics of Living Systems

    Dynamics of diffusive cell signaling relays

    Paul B Dieterle et al.
    The collective dynamics of cell signaling relays are at once dramatically sensitive to the system dimensionality and insensitive to many biological details.
    1. Cell Biology
    2. Physics of Living Systems

    Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm

    James F Pelletier et al.
    Live imaging of multiple cytoplasmic networks in frog egg extracts calls for new models for how egg cytoplasm is physically organized during cleavage divisions.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Hydrodynamics of sponge pumps and evolution of the sponge body plan

    Seyed Saeed Asadzadeh et al.
    The architecture of flagellated chambers in sponge pumps is linked to that of body plan, supporting the current view that the sponge aquiferous system evolved from an open-type filtration system.
    1. Physics of Living Systems

    Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility

    Elizabeth Eck et al.
    Confronting different models of chromatin accessibility with temporally resolved transcription profiles favors a scenario where transcription factors actively, rather than passively, drive chromatin from the inaccessible to the accessible state.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth

    Vivek V Thacker et al.
    Time-lapse imaging and the modular recreation of host physiology reveal that alveolar epithelial cells, potential permissive infection sites for Mycobacterium tuberculosis, can restrict early bacterial growth via surfactant secretion.