Browse our latest Physics of Living Systems articles

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    1. Cell Biology
    2. Physics of Living Systems

    The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch

    Robbert van der Pijl, Jochen Gohlke ... Coen Ottenheijm
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Roles of the membrane-binding motif and the C-terminal domain of RNase E in localization and diffusion in E. coli

    Laura Troyer, Yu-Huan Wang ... Sangjin Kim
    Single-molecule imaging uncovers how distinct membrane-binding motifs and the intrinsically disordered C-terminal domain control RNase E’s membrane association and diffusion, linking structural divergence to RNA-processing dynamics in bacteria.
    1. Developmental Biology
    2. Physics of Living Systems

    Migrating mesoderm cells self-organize into a dynamic meshwork structure during chick gastrulation

    Yukiko Nakaya, Mitsusuke Tarama ... Tatsuo Shibata
    A novel form of collective mesenchymal cell migration is identified during chick gastrulation, where a dynamic 3D meshwork supported by N-cadherin-mediated adhesion coordinates movement and enhances directional migration in the unconfined space between ectoderm and endoderm.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Non-equilibrium strategies enabling ligand specificity by signaling receptors

    Andrew Goetz, Jeremy Barrios ... Purushottam D Dixit
    Non-equilibrium thermodynamics allows signaling networks to signal downstream of certain ligands but avoid signaling from others.
    1. Physics of Living Systems

    Toward stable replication of genomic information in pools of RNA molecules

    Ludwig Burger, Ulrich Gerland
    Theoretical and computational analyses reveal environmental, compositional, kinetic, and thermodynamic constraints on a scenario where sequence information collectively stored in pools of RNA molecules is replicated via non-enzymatic RNA ligation.
    1. Neuroscience
    2. Physics of Living Systems

    A stretching mechanism evokes mechano-electrical transduction in auditory chordotonal neurons

    Atitheb Chaiyasitdhi, Manuela Nowotny ... Benjamin Warren
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Ecology
    2. Physics of Living Systems

    The dominant–egalitarian transition in species-rich communities

    David A Kessler, Nadav M Shnerb
    A model of a species-rich neutral ecosystem, perturbed by environmental noise impacting each species differently, predicts that for large noise the community is dominated by a few species, while for weaker noise it is more egalitarian, with many significant species.
    1. Physics of Living Systems

    The Matthew effect and early-career setbacks in research funding—a replication study

    Vincent Traag, Emer Brady ... Carter Bloch
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Physics of Living Systems

    Fragmentation and aggregation of cyanobacterial colonies

    Yuri Z Sinzato, Robert Uittenbogaard ... Maziyar Jalaal
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience
    2. Physics of Living Systems

    A Deep Learning Pipeline for Mapping in situ Network-level Neurovascular Coupling in Multi-photon Fluorescence Microscopy

    Matthew Rozak, James Mester ... Bojana Stefanovic
    Revised
    Reviewed Preprint v4
    Updated
    • Valuable
    • Solid