Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1+ cells via ciliary TGF-β signaling

    Han Xiao, Tao Zhang ... Hongbin Lu
    The proper mechanical stimulus could promote the migration of Prrx1+ cells to the injury site to enhance enthesis injury repair.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells

    Boyang Ren, Huan Xia ... Mingzhao Zhu
    Hematopoietic progenitor cells employ CD47 to engage thymic portal endothelial signal regulatory protein alpha for their transendothelial migration and thymic homing.
    1. Stem Cells and Regenerative Medicine

    Activation of the EGFR/MAPK pathway drives transdifferentiation of quiescent niche cells to stem cells in the Drosophila testis niche

    Leah J Greenspan, Margaret de Cuevas ... Erika L Matunis
    In the adult Drosophila testis, normally quiescent niche cells can be forced to re-enter the cell cycle and give rise to new stem cells in response to epidermal growth factor receptor signaling.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

    Diljeet Gill, Aled Parry ... Wolf Reik
    Transiently reprogramming human fibroblasts up to the maturation phase rejuvenates cells according to several aging markers whilst enabling them to return to their original identity.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Identification of bipotent progenitors that give rise to myogenic and connective tissues in mouse

    Alexandre Grimaldi, Glenda Comai ... Shahragim Tajbakhsh
    Combined lineage-tracing strategies, single-cell transcriptomic methods and in situ analyses identified mesodermal bipotent progenitors during craniofacial myogenesis that give rise to myogenic and connective tissues, thus redefining the lineage and evolutionary relationships between muscle and associated stroma.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity

    Chie Sugimoto, Yukie Murakami ... Hiroshi Wakao
    Mucosal-associated invariant T cells, an emerging member of the innate-like T cells abundant in humans bridging the innate and the adaptive immunity, could be exploited as a novel tool for cancer immunotherapy through cell reprogramming.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration

    Sahil H Shah, Lucio M Schiapparelli ... Jeffrey L Goldberg
    Transportomic analysis of the changes underlying neurodegeneration reveals the importance of Kif5a for neuronal survival and highlights the need to restore specific anterograde cargo transport to for regeneration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments

    Alwyn Dady, Lindsay Davidson ... Kate G Storey
    Comparison of human spinal cord rosette differentiation in vitro and following transplantation into heterologous embryonic environments, reveals cell-intrinsic constraint on human differentiation pace and the importance of timely extrinsic signalling for progression through an intrinsic human neural differentiation programme.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Paraxial mesoderm organoids model development of human somites

    Christoph Budjan, Shichen Liu ... Sahand Hormoz
    Human somites are formed in organoids from human pluripotent stem cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

    Naser Nasrollahzadeh, Peyman Karami ... Dominique P Pioletti
    The loading-induced temperature evolution phenomenon in the knee joint modulates chondrogenic cells response to loading and accordingly opens a new paradigm that is coined 'thermo-mechanobiology'.