Browse our latest Stem Cells and Regenerative Medicine articles

Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.

Telomere shortening with age promotes a switch from p53-dependent apoptosis to senescence prompted by tissue damage that triggers conflicting mTOR/AKT signalling, lower OxPhos defences and ROS, mitochondria dysfunction and senescence.

In the developing kidney, secreted molecules of the R-spondin family control progenitor cell proliferation and nephron formation by permitting WNT/β-catenin signalling.

Progenitors establish a single-cell length WNT morphogen gradient to transmit signals directionally and differentially to neighbors.

The ability of cartilaginous fishes to generate new cartilage through adulthood, and to spontaneously repair damaged cartilage, could shed light on novel cell-based therapies for cartilage injury in mammals.

Bioinformatic analysis of mesenchymal stem cell chondrogenesis identified a novel long noncoding RNA, GRASLND, which suppresses interferon signaling and enhances chondrogenesis.

A long non-coding RNA called GRASLND is essential to help stem cells create stable cartilage.

The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.

Blastoderm tissue organization and patterning in zebrafish explants is driven by a genetically encoded and controlled self-assembly mechanism, rather than a bonafide self-organization mechanism.

Efficient dedifferentiation is characterized by robustness to mutation, flexibility in ordering of cellular events and reversal of developmental changes along a single gene expression trajectory.