Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration

    Zhihao Jia, Yaohui Nie ... Shihuan Kuang
    Inhibition of Polo-like kinase that has been shown to exhibit antitumor effect unexpectedly disrupts muscle stem cell function, leading to developmental and regenerative failures.
    1. Stem Cells and Regenerative Medicine

    Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis

    Kefei Nina Li, Prachi Jain ... Tudorita Tumbar
    Hair follicle epithelium and skin vasculature remodeling are coordinated during quiescence, and their cross-talking is associated with the timing of stem cell activation.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

    Disi An, Ryosuke Fujiki ... Esteban Orlando Mazzoni
    Stem cell-derived motor neurons with differential ALS vulnerability identified proteasome activity as a possible mechanism that explains their differential sensitivity.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Epithelial geometry regulates spindle orientation and progenitor fate during formation of the mammalian epidermis

    Kimberly Box, Bradley W Joyce, Danelle Devenport
    Early in mammalian epidermal development, basal epidermal progenitor cells utilize packing and three-dimensional geometry, rather than cortical polarity cues, to inform division orientation and progenitor cell fate.
    1. Stem Cells and Regenerative Medicine

    Cell non-autonomous functions of S100a4 drive fibrotic tendon healing

    Jessica E Ackerman, Anne EC Nichols ... Alayna E Loiselle
    Inhibition of S100a4 represents a novel anti-fibrotic target to improve tendon healing.
    1. Stem Cells and Regenerative Medicine

    Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis

    Dayan J Li, Conor L McMann, Peter W Reddien
    NR4A is a broadly conserved transcription factor that is required for concordance of patterning information and anatomy at both ends of the planarian anterior-posterior axis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stem cell topography splits growth and homeostatic functions in the fish gill

    Julian Stolper, Elizabeth Mayela Ambrosio ... Lazaro Centanin
    The fish gill, an ever-growing organ with fast turnover rate, displays dedicated stem-cell populations for growth and homeostasis that are interchangeable upon external challenges.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    MicroRNA-deficient mouse embryonic stem cells acquire a functional interferon response

    Jeroen Witteveldt, Lisanne I Knol, Sara Macias
    MiRNA-mediated suppression of MAVS expression in embryonic stem cells is necessary to inactivate the type I interferon response.
    1. Stem Cells and Regenerative Medicine

    Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

    Joseph Herdy, Simon Schafer ... Fred H Gage
    An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

    Mohsen Afshar Bakooshli, Ethan S Lippmann ... Penney M Gilbert
    Human skeletal muscle progenitors and motor neurons self-organize in three-dimensional co-culture to form functional neuromuscular junctions that developmentally mature from the embryonic to the adult state.